USP33

Protein-coding gene in the species Homo sapiens

USP33

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2UZG

Identifiers

Aliases

USP33, VDU1, ubiquitin specific peptidase 33

External IDs

OMIM: 615146; MGI: 2159711; HomoloGene: 8996; GeneCards: USP33; OMA:USP33 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p31.1	Start	77,695,987 bp^[1]
Band	1p31.1	End	77,759,852 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 H3	Start	152,052,115 bp^[2]
Band	3\|3 H3	End	152,099,254 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cerebellar vermis

Brodmann area 23

retinal pigment epithelium

pons

lateral nuclear group of thalamus

mucosa of paranasal sinus

parietal pleura

primary visual cortex

endothelial cell

middle temporal gyrus

Top expressed in

neural layer of retina

ventromedial nucleus

lobe of cerebellum

ventral tegmental area

mammillary body

dorsomedial hypothalamic nucleus

pontine nuclei

habenula

lateral hypothalamus

dorsal tegmental nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	cysteine-type peptidase activity zinc ion binding metal ion binding peptidase activity ubiquitin binding protein binding thiol-dependent deubiquitinase cysteine-type endopeptidase activity hydrolase activity G protein-coupled receptor binding
Cellular component	cytoplasm cell body centrosome Golgi apparatus VCB complex focal adhesion nucleoplasm microtubule organizing center autophagosome perinuclear region of cytoplasm cytoskeleton cytosol
Biological process	endocytosis protein K48-linked deubiquitination ubiquitin-dependent protein catabolic process regulation of G protein-coupled receptor signaling pathway centrosome duplication cellular response to starvation protein stabilization negative regulation of protein binding proteolysis axon guidance regulation of autophagy protein K63-linked deubiquitination positive regulation of protein binding cell migration protein deubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23032


170822

Ensembl


ENSG00000077254


ENSMUSG00000025437

UniProt


Q8TEY7


Q8R5K2

RefSeq (mRNA)


NM_015017 NM_201624 NM_201626


NM_001076676 NM_001252486 NM_133247 NM_001355666

RefSeq (protein)

NP_055832 NP_963918 NP_963920 NP_001364359 NP_001364360
NP_001364361 NP_001364362 NP_001364363 NP_001364364 NP_001364365 NP_001364366 NP_001364367 NP_001364368


NP_001070144 NP_001239415 NP_573510 NP_001342595

Location (UCSC)

Chr 1: 77.7 – 77.76 Mb

Chr 3: 152.05 – 152.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.^[5]^[6]

Interactions

USP33 has been shown to interact with DIO2,^[7] SELENBP1^[8] and Von Hippel–Lindau tumor suppressor.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077254 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025437 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
^ "Entrez Gene: USP33 ubiquitin specific peptidase 33".
^ Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (Jul 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
^ Jeong JY, Wang Y, Sytkowski AJ (Feb 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.
^ Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.
Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G (2002). "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochem. Biophys. Res. Commun. 294 (3): 700–709. doi:10.1016/S0006-291X(02)00534-X. PMID 12056827.
Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Allen MD, Bycroft M (2007). "The solution structure of the ZnF UBP domain of USP33/VDU1". Protein Sci. 16 (9): 2072–2075. doi:10.1110/ps.072967807. PMC 2206988. PMID 17766394.