UNC93B1

Protein-coding gene in the species Homo sapiens
UNC93B1
Identifiers
AliasesUNC93B1, IIAE1, UNC93, UNC93B, Unc-93B1, unc-93 homolog B1 (C. elegans), unc-93 homolog B1, TLR signaling regulator
External IDsOMIM: 608204; MGI: 1859307; HomoloGene: 41325; GeneCards: UNC93B1; OMA:UNC93B1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for UNC93B1
Genomic location for UNC93B1
Band11q13.2Start67,991,100 bp[1]
End68,004,982 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for UNC93B1
Genomic location for UNC93B1
Band19|19 AStart3,985,186 bp[2]
End3,999,340 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • monocyte

  • olfactory zone of nasal mucosa

  • spleen

  • bone marrow cells

  • appendix

  • right lung

  • right uterine tube

  • upper lobe of left lung

  • minor salivary glands
Top expressed in
  • granulocyte

  • stroma of bone marrow

  • mesenteric lymph nodes

  • spleen

  • tibiofemoral joint

  • calvaria

  • ankle joint

  • ankle

  • submandibular gland

  • subcutaneous adipose tissue
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • Toll-like receptor binding
Cellular component
  • integral component of membrane
  • early phagosome
  • Golgi membrane
  • endosome
  • lysosome
  • phagocytic vesicle
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • membrane
  • cytoplasmic vesicle
Biological process
  • toll-like receptor 9 signaling pathway
  • intracellular protein transport
  • toll-like receptor 3 signaling pathway
  • adaptive immune response
  • defense response to virus
  • toll-like receptor 7 signaling pathway
  • toll-like receptor signaling pathway
  • immune system process
  • innate immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81622

54445

Ensembl

ENSG00000110057

ENSMUSG00000036908

UniProt

Q9H1C4

Q8VCW4

RefSeq (mRNA)

NM_030930

NM_001161428
NM_019449

RefSeq (protein)

NP_112192

NP_001154900
NP_062322

Location (UCSC)Chr 11: 67.99 – 68 MbChr 19: 3.99 – 4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Unc-93 homolog B1 (C. elegans), also known as UNC93B1, is a protein which in humans is encoded by the UNC93B1 gene.[5][6]

Function

This gene encodes a protein with similarity to the Caenorhabditis elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110057 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036908 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: UNC93B1 unc-93 homolog B1 (C. elegans)".
  6. ^ Kashuba VI, Protopopov AI, Kvasha SM, Gizatullin RZ, Wahlestedt C, Kisselev LL, Klein G, Zabarovsky ER (January 2002). "hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein". Gene. 283 (1–2): 209–17. doi:10.1016/S0378-1119(01)00856-3. PMID 11867227.

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Kashuba VI, Protopopov AI, Kvasha SM, et al. (2002). "hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein". Gene. 283 (1–2): 209–17. doi:10.1016/S0378-1119(01)00856-3. PMID 11867227.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Arnlöv J, Sundström J, Lind L, et al. (2006). "hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men". Eur. J. Heart Fail. 7 (6): 958–65. doi:10.1016/j.ejheart.2004.06.009. PMID 16111919. S2CID 22339419.
  • Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.
  • Casrouge A, Zhang SY, Eidenschenk C, et al. (2006). "Herpes simplex virus encephalitis in human UNC-93B deficiency". Science. 314 (5797): 308–12. Bibcode:2006Sci...314..308C. doi:10.1126/science.1128346. PMID 16973841. S2CID 12501759.


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