UBA5

Protein-coding gene in the species Homo sapiens
UBA5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3GUC, 3H8V, 5HKH

Identifiers
AliasesUBA5, THIFP1, UBE1DC1, ubiquitin like modifier activating enzyme 5, SCAR24, EIEE44, DEE44
External IDsOMIM: 610552; MGI: 1913913; HomoloGene: 11738; GeneCards: UBA5; OMA:UBA5 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for UBA5
Genomic location for UBA5
Band3q22.1Start132,654,446 bp[1]
End132,679,794 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for UBA5
Genomic location for UBA5
Band9|9 F1Start103,923,798 bp[2]
End103,940,333 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • parotid gland

  • anterior pituitary

  • Achilles tendon

  • minor salivary glands

  • secondary oocyte
Top expressed in
  • lacrimal gland

  • Ileal epithelium

  • parotid gland

  • seminal vesicula

  • fossa

  • islet of Langerhans

  • supraoptic nucleus

  • facial motor nucleus

  • substantia nigra

  • median eminence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein binding
  • ubiquitin-like modifier activating enzyme activity
  • ATP binding
  • metal ion binding
  • UFM1 activating enzyme activity
Cellular component
  • cytoplasm
  • intracellular membrane-bounded organelle
  • nucleus
  • cytosol
  • Golgi apparatus
Biological process
  • regulation of intracellular estrogen receptor signaling pathway
  • protein K69-linked ufmylation
  • response to endoplasmic reticulum stress
  • protein ufmylation
  • neuromuscular process
  • protein modification by small protein conjugation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79876

66663

Ensembl

ENSG00000081307

ENSMUSG00000032557

UniProt

Q9GZZ9

Q8VE47

RefSeq (mRNA)

NM_024818
NM_198329
NM_001320210
NM_001321238
NM_001321239

NM_025692

RefSeq (protein)

NP_001307139
NP_001308167
NP_001308168
NP_079094
NP_938143

NP_079968

Location (UCSC)Chr 3: 132.65 – 132.68 MbChr 9: 103.92 – 103.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene.[5][6][7]

This gene encodes a member of the E1-like activating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000081307 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032557 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K (May 2004). "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier". EMBO J. 23 (9): 1977–86. doi:10.1038/sj.emboj.7600205. PMC 404325. PMID 15071506.
  7. ^ a b "Entrez Gene: UBE1DC1 ubiquitin-activating enzyme E1-domain containing 1".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Dou T, Gu S, Liu J, et al. (2006). "Isolation and characterization of ubiquitin-activating enzyme E1-domain containing 1, UBE1DC1". Mol. Biol. Rep. 32 (4): 265–71. doi:10.1007/s11033-005-4822-y. PMID 16328888. S2CID 24569517.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Overview of all the structural information available in the PDB for UniProt: Q9GZZ9 (Human Ubiquitin-like modifier-activating enzyme 5 (UBE1DC1)) at the PDBe-KB.


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