Protein-coding gene in the species Homo sapiens
TEKT1 |
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Identifiers |
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Aliases | TEKT1, tektin 1 |
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External IDs | OMIM: 609002; MGI: 1333819; HomoloGene: 7973; GeneCards: TEKT1; OMA:TEKT1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17p13.1 | Start | 6,789,133 bp[1] |
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End | 6,831,761 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 B4 | Start | 72,235,548 bp[2] |
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End | 72,253,268 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - bronchial epithelial cell
- right uterine tube
- olfactory zone of nasal mucosa
- mucosa of paranasal sinus
- left testis
- right testis
- sperm
- epithelium of nasopharynx
- testicle
- nasal epithelium
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| Top expressed in | - spermatid
- seminiferous tubule
- spermatocyte
- utricle
- olfactory epithelium
- morula
- vestibular sensory epithelium
- Epithelium of choroid plexus
- right lung lobe
- choroid plexus of fourth ventricle
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | - cytoplasm
- microtubule cytoskeleton
- cell projection
- cilium
- microtubule
- cytoskeleton
- nucleus
- sperm flagellum
- motile cilium
| Biological process | - flagellated sperm motility
- cilium assembly
- cilium movement involved in cell motility
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001282006 NM_001282007 NM_011569 |
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RefSeq (protein) | | |
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NP_001268935 NP_001268936 NP_035699 |
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Location (UCSC) | Chr 17: 6.79 – 6.83 Mb | Chr 11: 72.24 – 72.25 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Tektin-1 is a protein that in humans is encoded by the TEKT1 gene.[5][6]
Function
This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167858 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020799 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: tektin 1".
- ^ Xu M, Zhou Z, Cheng C, Zhao W, Tang R, Huang Y, Wang W, Xu J, Zeng L, Xie Y, Mao Y (December 2001). "Cloning and characterization of a novel human TEKTIN1 gene". Int. J. Biochem. Cell Biol. 33 (12): 1172–82. doi:10.1016/S1357-2725(01)00089-9. PMID 11606253.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Newby PR, Pickles OJ, Mazumdar S, et al. (2010). "Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study". Eur. J. Hum. Genet. 18 (9): 1021–6. doi:10.1038/ejhg.2010.55. PMC 2987410. PMID 20442750.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Iguchi N, Tanaka H, Nakamura Y, et al. (2002). "Cloning and characterization of the human tektin-t gene". Mol. Hum. Reprod. 8 (6): 525–30. doi:10.1093/molehr/8.6.525. PMID 12029069.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.