TXNL4B

Protein-coding gene in the species Homo sapiens

TXNL4B

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1XBS, 3GIX, 4IN0

Identifiers

Aliases

TXNL4B, DLP, Dim2, thioredoxin like 4B

External IDs

OMIM: 617722; MGI: 2443724; HomoloGene: 9880; GeneCards: TXNL4B; OMA:TXNL4B - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q22.2	Start	72,044,289 bp^[1]
Band	16q22.2	End	72,094,431 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 D3	Start	110,292,524 bp^[2]
Band	8\|8 D3	End	110,300,683 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

internal globus pallidus

gonad

monocyte

optic nerve

pancreatic ductal cell

left ovary

right lobe of liver

endothelial cell

secondary oocyte

testicle

Top expressed in

granulocyte

spermatid

spermatocyte

zygote

otolith organ

utricle

seminiferous tubule

secondary oocyte

submandibular gland

embryo

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	U5 snRNP nucleus nucleoplasm cytosol spliceosomal complex U4/U6 x U5 tri-snRNP complex
Biological process	mRNA splicing, via spliceosome cell cycle mRNA processing spliceosomal complex assembly RNA splicing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54957


234723

Ensembl


ENSG00000140830


ENSMUSG00000031723

UniProt


Q9NX01


Q8BUH1

RefSeq (mRNA)


NM_017853 NM_001142317 NM_001142318 NM_001324354 NM_001324355


NM_175646

RefSeq (protein)


NP_001135789 NP_001135790 NP_001311283 NP_001311284 NP_060323


NP_783577

Location (UCSC)

Chr 16: 72.04 – 72.09 Mb

Chr 8: 110.29 – 110.3 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Thioredoxin-like protein 4B is a protein that in humans is encoded by the TXNL4B gene.^[5]^[6]

Interactions

TXNL4B has been shown to interact with PRPF6.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140830 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031723 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Sun X, Zhang H, Wang D, Ma D, Shen Y, Shang Y (Jul 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J Biol Chem. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. PMID 15161931.
^ "Entrez Gene: TXNL4B thioredoxin-like 4B".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang YZ, Gould KL, Dunbrack RL JR, Cheng H, Roder H, Golemis EA (2001). "The evolutionarily conserved Dim1 protein defines a novel branch of the thioredoxin fold superfamily" (PDF). Physiol. Genomics. 1 (3): 109–18. doi:10.1152/physiolgenomics.1999.1.3.109. PMID 11015569. S2CID 16086223.
Schelling P, Claus MT, Johner R, Marquez VE, Schulz GE, Scapozza L (2004). "Biochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cells". J. Biol. Chem. 279 (31): 32832–8. doi:10.1074/jbc.M313343200. PMID 15163659.
Simeoni F, Arvai A, Bello P, Gondeau C, Hopfner KP, Neyroz P, Heitz F, Tainer J, Divita G (2005). "Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2". Biochemistry. 44 (36): 11997–2008. doi:10.1021/bi050427o. PMID 16142897.
Jin T, Howard AJ, Golemis EA, Wang Y, Zhang YZ (2006). "Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B". Acta Crystallographica Section F. 61 (Pt 3): 282–4. doi:10.1107/S1744309105002861. PMC 1952293. PMID 16511018.