TTLL3

Protein-coding gene in the species Homo sapiens
TTLL3
Identifiers
AliasesTTLL3, HOTTL, tubulin tyrosine ligase like 3
External IDsMGI: 2141418; HomoloGene: 134361; GeneCards: TTLL3; OMA:TTLL3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TTLL3
Genomic location for TTLL3
Band3p25.3Start9,808,086 bp[1]
End9,855,138 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for TTLL3
Genomic location for TTLL3
Band6|6 E3Start113,366,221 bp[2]
End113,391,548 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • left ovary

  • right ovary

  • canal of the cervix

  • right testis

  • left testis

  • sural nerve

  • left uterine tube

  • granulocyte

  • gastric mucosa
Top expressed in
  • granulocyte

  • Rostral migratory stream

  • spermatid

  • utricle

  • neural layer of retina

  • seminiferous tubule

  • cerebellar cortex

  • lumbar spinal ganglion

  • olfactory epithelium

  • spermatocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • ATP binding
  • protein-glycine ligase activity, initiating
  • nucleotide binding
  • ligase activity
  • protein-glycine ligase activity
Cellular component
  • microtubule
  • axoneme
  • microtubule cytoskeleton
  • cytoplasm
  • cell projection
  • cilium
  • cytoskeleton
  • cytosol
Biological process
  • axoneme assembly
  • cilium assembly
  • protein polyglycylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26140

101100

Ensembl

ENSG00000214021

ENSMUSG00000030276

UniProt

Q9Y4R7

A4Q9E5

RefSeq (mRNA)

NM_001025930
NM_015644
NM_001366051

NM_001142732
NM_133923

RefSeq (protein)

NP_001021100
NP_001352980

NP_001136204
NP_598684

Location (UCSC)Chr 3: 9.81 – 9.86 MbChr 6: 113.37 – 113.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin tyrosine ligase-like family, member 3 is a protein that in humans is encoded by the TTLL3 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214021 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030276 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Tubulin tyrosine ligase-like family, member 3". Retrieved 2011-09-21.

Further reading

  • Trichet V, Ruault M, Roizès G, De Sario A (October 2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene. 257 (1): 109–117. doi:10.1016/S0378-1119(00)00383-8. PMID 11054573.
  • Rogowski K, Juge F, van Dijk J, Wloga D, Strub JM, Levilliers N, et al. (June 2009). "Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation". Cell. 137 (6): 1076–1087. doi:10.1016/j.cell.2009.05.020. PMID 19524510. S2CID 953190.
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