TROVE2

Protein-coding gene in the species Homo sapiens

RO60

Identifiers

Aliases

RO60, RORNP, SSA2, TROVE domain family member 2, Ro60, Y RNA binding protein, TROVE2

External IDs

OMIM: 600063; MGI: 106652; HomoloGene: 3383; GeneCards: RO60; OMA:RO60 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q31.2	Start	193,059,454 bp^[1]
Band	1q31.2	End	193,091,777 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1 F\|1 62.54 cM	Start	143,626,528 bp^[2]
Band	1 F\|1 62.54 cM	End	143,652,806 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nipple

external globus pallidus

dorsal motor nucleus of vagus nerve

inferior ganglion of vagus nerve

inferior olivary nucleus

optic nerve

sperm

pars reticulata

renal medulla

trabecular bone

Top expressed in

superior surface of tongue

gallbladder

Rostral migratory stream

molar

cerebellar vermis

pineal gland

lobe of cerebellum

trigeminal ganglion

cingulate gyrus

habenula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	U2 snRNA binding metal ion binding RNA binding
Cellular component	nucleus cytoplasm nucleoplasm cytosol ribonucleoprotein complex
Biological process	immune system development transcription by RNA polymerase III smoothened signaling pathway response to UV cilium assembly cell projection organization regulation of gene expression cellular response to interferon-alpha
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6738


20822

Ensembl


ENSG00000116747


ENSMUSG00000018199

UniProt


P10155


O08848

RefSeq (mRNA)

NM_001042369 NM_001042370 NM_001173524 NM_001173525 NM_004600
NM_001331020


NM_013835

RefSeq (protein)

NP_001035828 NP_001035829 NP_001166995 NP_001166996 NP_001317949
NP_004591


NP_038863

Location (UCSC)

Chr 1: 193.06 – 193.09 Mb

Chr 1: 143.63 – 143.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

60 kDa SS-A/Ro ribonucleoprotein is a protein that in humans is encoded by the TROVE2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116747 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018199 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Frank MB, Mattei MG (Jun 1994). "Mapping of the human 60,000 M(r) Ro/SSA locus: the genes for three Ro/SSA autoantigens are located on separate chromosomes". Immunogenetics. 39 (6): 428–31. doi:10.1007/bf00176161. PMID 8188321. S2CID 9772708.
^ "Entrez Gene: TROVE2 TROVE domain family, member 2".

James JA, Dickey WD, Fujisaku A, et al. (1990). "Antigenicity of a recombinant Ro (SS-A) fusion protein". Arthritis Rheum. 33 (1): 102–6. doi:10.1002/art.1780330114. PMID 1689160.
Jitsukawa T, Nakajima S, Usui J, Watanabe H (1991). "Detection of anti-nuclear antibodies from patients with systemic rheumatic diseases by ELISA using HEp-2 cell nuclei". J. Clin. Lab. Anal. 5 (1): 49–53. doi:10.1002/jcla.1860050109. PMID 1999763. S2CID 25495352.
Ben-Chetrit E, Gandy BJ, Tan EM, Sullivan KF (1989). "Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen". J. Clin. Invest. 83 (4): 1284–92. doi:10.1172/JCI114013. PMC 303819. PMID 2649513.
Deutscher SL, Harley JB, Keene JD (1989). "Molecular analysis of the 60-kDa human Ro ribonucleoprotein". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9479–83. doi:10.1073/pnas.85.24.9479. PMC 282776. PMID 3200833.
Lee LA, Harmon CE, Huff JC, et al. (1985). "The demonstration of SS-A/Ro antigen in human fetal tissues and in neonatal and adult skin". J. Invest. Dermatol. 85 (2): 143–6. doi:10.1111/1523-1747.ep12276566. PMID 3926904.
Wolin SL, Steitz JA (1984). "The Ro small cytoplasmic ribonucleoproteins: identification of the antigenic protein and its binding site on the Ro RNAs". Proc. Natl. Acad. Sci. U.S.A. 81 (7): 1996–2000. Bibcode:1984PNAS...81.1996W. doi:10.1073/pnas.81.7.1996. PMC 345423. PMID 6201849.
Harmon CE, Deng JS, Peebles CL, Tan EM (1984). "The importance of tissue substrate in the SS-A/Ro antigen-antibody system". Arthritis Rheum. 27 (2): 166–73. doi:10.1002/art.1780270207. PMID 6421292.
Fritzler MJ, Miller BJ (1995). "Detection of autoantibodies to SS-A/Ro by indirect immunofluorescence using a transfected and overexpressed human 60 kD Ro autoantigen in HEp-2 cells". J. Clin. Lab. Anal. 9 (3): 218–24. doi:10.1002/jcla.1860090312. PMID 7602431. S2CID 39372814.
Chan EK, Tan EM, Ward DC, Matera AG (1995). "Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization". Genomics. 23 (1): 298–300. doi:10.1006/geno.1994.1502. PMID 7829096.
Wang D, Buyon JP, Zhu W, Chan EK (1999). "Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies". J. Clin. Invest. 104 (9): 1265–75. doi:10.1172/JCI8003. PMC 409828. PMID 10545525.
Kurien BT, Chambers TL, Thomas PY, et al. (2001). "Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDa Ro/SSA and 52 kDa Ro/SSA". Scand. J. Immunol. 53 (3): 268–76. doi:10.1046/j.1365-3083.2001.00870.x. PMID 11251884.
Fouraux MA, Bouvet P, Verkaart S, et al. (2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". J. Mol. Biol. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. hdl:2066/121576. PMID 12096904.
McArthur C, Wang Y, Veno P, et al. (2002). "Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha". Arch. Oral Biol. 47 (6): 443–8. doi:10.1016/S0003-9969(02)00025-0. PMID 12102760.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Belisova A, Semrad K, Mayer O, et al. (2005). "RNA chaperone activity of protein components of human Ro RNPs". RNA. 11 (7): 1084–94. doi:10.1261/rna.7263905. PMC 1370793. PMID 15928345.
Hennig J, Ottosson L, Andrésen C, et al. (2005). "Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52". J. Biol. Chem. 280 (39): 33250–61. doi:10.1074/jbc.M503066200. PMID 15964842.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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