TRIM31

Protein-coding gene in the species Homo sapiens
TRIM31
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2YSJ, 2YSL

Identifiers
AliasesTRIM31, C6orf13, HCG1, HCGI, RNF, tripartite motif containing 31
External IDsOMIM: 609316; MGI: 2385051; HomoloGene: 17137; GeneCards: TRIM31; OMA:TRIM31 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for TRIM31
Genomic location for TRIM31
Band6p22.1Start30,102,897 bp[1]
End30,113,090 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for TRIM31
Genomic location for TRIM31
Band17|17 B1Start37,209,010 bp[2]
End37,221,106 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • rectum

  • duodenum

  • appendix

  • gallbladder

  • urinary bladder

  • testicle

  • epithelium of colon

  • right testis

  • left testis
Top expressed in
  • intestinal villus

  • jejunum

  • duodenum

  • left colon

  • ileum

  • epithelium of small intestine

  • Paneth cell

  • crypt of lieberkuhn of small intestine

  • migratory enteric neural crest cell

  • zygote
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • metal ion binding
  • transferase activity
Cellular component
  • cytoplasm
  • cytosol
  • intracellular anatomical structure
  • mitochondrion
Biological process
  • positive regulation of DNA-binding transcription factor activity
  • protein ubiquitination
  • interferon-gamma-mediated signaling pathway
  • negative regulation of viral transcription
  • innate immune response
  • negative regulation of viral entry into host cell
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11074

224762

Ensembl
ENSG00000223531
ENSG00000137397
ENSG00000233573
ENSG00000224168
ENSG00000225130

ENSG00000226402
ENSG00000224542
ENSG00000204616

ENSMUSG00000058063

UniProt

Q9BZY9
Q2L6J1

Q8R0K2

RefSeq (mRNA)

NM_007028

NM_146077

RefSeq (protein)

NP_008959
NP_008959.3

NP_666189

Location (UCSC)Chr 6: 30.1 – 30.11 MbChr 17: 37.21 – 37.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene.[5][6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified.[6]

Interactions

TRIM31 has been shown to interact with TRIM23.[5]

References

  1. ^ a b c ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 GRCh38: Ensembl release 89: ENSG00000223531, ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058063 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. ^ a b "Entrez Gene: TRIM31 tripartite motif-containing 31".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • el Kahloun A, Chauvel B, Mauvieux V, et al. (1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55–60. doi:10.1093/hmg/2.1.55. PMID 8490624.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
  • Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.


  • v
  • t
  • e