TRAT1

Protein-coding gene in the species Homo sapiens
TRAT1
Identifiers
AliasesTRAT1, TCRIM, TRIM, HSPC062, pp29/30, T cell receptor associated transmembrane adaptor 1, T-cell receptor associated transmembrane adaptor 1
External IDsOMIM: 604962; MGI: 1924897; HomoloGene: 41130; GeneCards: TRAT1; OMA:TRAT1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TRAT1
Genomic location for TRAT1
Band3q13.13Start108,822,770 bp[1]
End108,855,005 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for TRAT1
Genomic location for TRAT1
Band16|16 B5Start48,551,137 bp[2]
End48,592,384 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • thymus

  • buccal mucosa cell

  • lymph node

  • testicle

  • blood

  • granulocyte

  • appendix

  • epithelium of nasopharynx

  • spleen

  • epithelium of colon
Top expressed in
  • thymus

  • blood

  • mesenteric lymph nodes

  • embryo

  • spleen

  • subcutaneous adipose tissue

  • superior frontal gyrus

  • gastrula

  • primary visual cortex

  • vastus lateralis muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transmembrane receptor protein tyrosine kinase adaptor activity
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Cellular component
  • integral component of membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
  • T cell receptor complex
Biological process
  • positive regulation of calcium-mediated signaling
  • adaptive immune response
  • immune system process
  • positive regulation of T cell receptor signaling pathway
  • negative regulation of transport
  • cellular defense response
  • T cell receptor signaling pathway
  • negative regulation of receptor recycling
  • signal transduction
  • phosphatidylinositol phosphate biosynthetic process
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • positive regulation of protein kinase B signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50852

77647

Ensembl

ENSG00000163519

ENSMUSG00000030775

UniProt

Q6PIZ9

Q3UU67

RefSeq (mRNA)

NM_016388
NM_001317747

NM_198297

RefSeq (protein)

NP_001304676
NP_057472

NP_938039

Location (UCSC)Chr 3: 108.82 – 108.86 MbChr 16: 48.55 – 48.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell receptor-associated transmembrane adapter 1 is a protein that in humans is encoded by the TRAT1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163519 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030775 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Mar 2000). "Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM)". Immunogenetics. 51 (2): 154–8. doi:10.1007/s002510050024. PMID 10663578. S2CID 43325566.
  6. ^ Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B (Sep 1998). "T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane". J Exp Med. 188 (3): 561–75. doi:10.1084/jem.188.3.561. PMC 2212462. PMID 9687533.
  7. ^ "Entrez Gene: TRAT1 T cell receptor associated transmembrane adaptor 1".

Further reading

  • Zhang W, Samelson LE (2000). "The role of membrane-associated adaptors in T cell receptor signalling". Semin. Immunol. 12 (1): 35–41. doi:10.1006/smim.2000.0205. PMID 10723796.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Kirchgessner H, Dietrich J, Scherer J, et al. (2001). "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain". J. Exp. Med. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011. S2CID 340034.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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