TPD52L2

Protein-coding gene in the species Homo sapiens
TPD52L2
Identifiers
AliasesTPD52L2, D54, TPD54, tumor protein D52 like 2, TPD52 like 2
External IDsOMIM: 603747; MGI: 1913564; HomoloGene: 2469; GeneCards: TPD52L2; OMA:TPD52L2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for TPD52L2
Genomic location for TPD52L2
Band20q13.33Start63,865,228 bp[1]
End63,891,545 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for TPD52L2
Genomic location for TPD52L2
Band2|2 H4Start181,138,935 bp[2]
End181,159,759 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right coronary artery

  • ascending aorta

  • popliteal artery

  • tibial arteries

  • stromal cell of endometrium

  • Descending thoracic aorta

  • gastric mucosa

  • left coronary artery

  • smooth muscle tissue

  • ectocervix
Top expressed in
  • saccule

  • otic placode

  • morula

  • genital tubercle

  • secondary oocyte

  • zygote

  • tail of embryo

  • blastocyst

  • condyle

  • otic vesicle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein homodimerization activity
  • protein heterodimerization activity
  • RNA binding
  • catalytic activity
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
Biological process
  • regulation of cell population proliferation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7165

66314

Ensembl

ENSG00000101150

ENSMUSG00000000827

UniProt

O43399
Q6FGS1

Q9CYZ2

RefSeq (mRNA)
NM_001243891
NM_001243892
NM_001243894
NM_001243895
NM_003288

NM_199359
NM_199360
NM_199361
NM_199362
NM_199363

NM_001291197
NM_001291200
NM_001291201
NM_001291202
NM_001291203

NM_001291204
NM_025482
NM_001373959
NM_001373960
NM_001373961

RefSeq (protein)
NP_001230820
NP_001230821
NP_001230823
NP_001230824
NP_003279

NP_955391
NP_955392
NP_955393
NP_955394
NP_955395
NP_003279.2

NP_001278126
NP_001278129
NP_001278130
NP_001278131
NP_001278132

NP_001278133
NP_079758
NP_001360888
NP_001360889
NP_001360890
NP_001393282
NP_001393283
NP_001393284
NP_001393285
NP_001393286
NP_001393287
NP_001393288
NP_001393289
NP_001393290
NP_001393291
NP_001393292

Location (UCSC)Chr 20: 63.87 – 63.89 MbChr 2: 181.14 – 181.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene.[5][6]

Interactions

TPD52L2 has been shown to interact with TPD52L1[5] and TPD52.[5]

Cellular function

TPD52L2 has a role in membrane traffic.[7] TPD52L2 is found on small transport vesicles, termed intracellular nanovesicles, that transfer proteins between different cellular compartments. When TPD52L2 is depleted from HeLa cells, the following trafficking pathways are impaired: anterograde traffic, recycling of cargo and Golgi integrity.[7] Proteomic analysis indicates that TPD52L2 is one of the most abundant proteins expressed in HeLa cells.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101150 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000827 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Byrne JA, Nourse CR, Basset P, Gunning P (Mar 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.
  6. ^ "Entrez Gene: TPD52L2 tumor protein D52-like 2".
  7. ^ a b Larocque G, La-Borde PJ, Clarke NI, Carter NJ, Royle SJ (2019). "Tumor protein D54 defines a new class of intracellular transport vesicle". J Cell Biol. 219 (1). doi:10.1083/jcb.201812044. PMC 7039206. PMID 31672706.
  8. ^ Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M (2017). "A human interactome in three quantitative dimensions organized by stoichiometries and abundances". Cell. 163 (3): 712–23. doi:10.1016/j.cell.2015.09.053. PMID 26496610.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Byrne JA, Mattei MG, Basset P (1996). "Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52)". Genomics. 35 (3): 523–32. doi:10.1006/geno.1996.0393. PMID 8812487.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nourse CR, Mattei MG, Gunning P, Byrne JA (1998). "Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts". Biochim. Biophys. Acta. 1443 (1–2): 155–68. doi:10.1016/S0167-4781(98)00211-5. PMID 9838088.
  • Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA (2001). "Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system". Genomics. 76 (1–3): 81–8. doi:10.1006/geno.2001.6610. PMID 11549320.
  • Boutros R, Byrne JA (2005). "D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells". Exp. Cell Res. 310 (1): 152–65. doi:10.1016/j.yexcr.2005.07.009. PMID 16112108.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2006). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
  • Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J (2006). "A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins". Biochem. Biophys. Res. Commun. 344 (3): 798–806. doi:10.1016/j.bbrc.2006.03.208. PMID 16631610.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


  • v
  • t
  • e