TOM1L1

Protein-coding gene in the species Homo sapiens
TOM1L1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3RRU

Identifiers
AliasesTOM1L1, OK/KNS-CL.3, SRCASM, target of myb1 like 1 membrane trafficking protein
External IDsOMIM: 604701; MGI: 1919193; HomoloGene: 38055; GeneCards: TOM1L1; OMA:TOM1L1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for TOM1L1
Genomic location for TOM1L1
Band17q22Start54,899,387 bp[1]
End54,961,956 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for TOM1L1
Genomic location for TOM1L1
Band11 D|11 55.47 cMStart90,534,291 bp[2]
End90,579,192 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • duodenum

  • islet of Langerhans

  • body of pancreas

  • rectum

  • kidney tubule

  • right lobe of liver

  • corpus epididymis

  • body of stomach

  • human kidney
Top expressed in
  • seminal vesicula

  • white matter of spinal cord

  • yolk sac

  • lens

  • tail of embryo

  • zygote

  • genital tubercle

  • duodenum

  • stomach

  • choroid plexus of fourth ventricle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • SH3 domain binding
  • clathrin binding
  • protein kinase activator activity
  • ubiquitin binding
  • protein binding
  • protein kinase binding
Cellular component
  • cytoplasm
  • cytosol
  • endosome
  • Golgi apparatus
  • membrane
  • intracellular anatomical structure
  • Golgi stack
  • lysosome
  • endosome membrane
  • extracellular exosome
Biological process
  • regulation of DNA biosynthetic process
  • negative regulation of mitotic nuclear division
  • positive regulation of protein autophosphorylation
  • protein transport
  • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
  • intracellular protein transport
  • activation of protein kinase activity
  • signal transduction
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10040

71943

Ensembl

ENSG00000141198

ENSMUSG00000020541

UniProt

O75674

Q923U0

RefSeq (mRNA)

NM_005486
NM_001321173
NM_001321174
NM_001321175
NM_001321176

NM_028011
NM_001357543
NM_001357544
NM_001357547

RefSeq (protein)

NP_001308102
NP_001308103
NP_001308104
NP_001308105
NP_005477

NP_082287
NP_001344472
NP_001344473
NP_001344476

Location (UCSC)Chr 17: 54.9 – 54.96 MbChr 11: 90.53 – 90.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TOM1-like protein 1 is a protein that in humans is encoded by the TOM1L1 gene.[5][6][7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141198 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020541 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP (Aug 1999). "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM". Genomics. 57 (3): 380–8. doi:10.1006/geno.1998.5739. PMID 10329004.
  6. ^ Puertollano R (Mar 2005). "Interactions of TOM1L1 with the multivesicular body sorting machinery". J Biol Chem. 280 (10): 9258–64. doi:10.1074/jbc.M412481200. PMID 15611048.
  7. ^ Zhang J, Suzuki K, Hitomi T, Siraganian RP (Dec 2007). "TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cells". J Biol Chem. 282 (52): 37669–77. doi:10.1074/jbc.M705168200. PMID 17977829.
  8. ^ "Entrez Gene: TOM1L1 target of myb1 (chicken)-like 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Seykora JT, Mei L, Dotto GP, Stein PL (2002). "'Srcasm: a novel Src activating and signaling molecule". J. Biol. Chem. 277 (4): 2812–22. doi:10.1074/jbc.M106813200. PMID 11711534.
  • Ministerial Meeting on Population of the Non-Aligned Movement (1993: Bali) (1995). "Non-aligned movement support for South-South collaboration in the field of population and family planning". Integration (Tokyo, Japan) (40): 37–42. PMID 12345679.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Katoh Y, Shiba Y, Mitsuhashi H, et al. (2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". J. Biol. Chem. 279 (23): 24435–43. doi:10.1074/jbc.M400059200. PMID 15047686.
  • Li W, Marshall C, Mei L, et al. (2005). "Srcasm modulates EGF and Src-kinase signaling in keratinocytes". J. Biol. Chem. 280 (7): 6036–46. doi:10.1074/jbc.M406546200. PMID 15579470.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.


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