TNPO2

Protein-coding gene in the species Homo sapiens
TNPO2
Identifiers
AliasesTNPO2, IPO3, KPNB2B, TRN2, transportin 2
External IDsOMIM: 603002; MGI: 2384849; HomoloGene: 8381; GeneCards: TNPO2; OMA:TNPO2 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for TNPO2
Genomic location for TNPO2
Band19p13.13Start12,699,194 bp[1]
End12,724,011 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for TNPO2
Genomic location for TNPO2
Band8|8 C3Start85,763,544 bp[2]
End85,784,212 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • inferior olivary nucleus

  • dorsal motor nucleus of vagus nerve

  • entorhinal cortex

  • lateral nuclear group of thalamus

  • pons

  • Brodmann area 46

  • nipple

  • ventral tegmental area

  • superior vestibular nucleus

  • orbitofrontal cortex
Top expressed in
  • perirhinal cortex

  • entorhinal cortex

  • CA3 field

  • visual cortex

  • Ileal epithelium

  • corneal stroma

  • primary visual cortex

  • superior frontal gyrus

  • dentate gyrus of hippocampal formation granule cell

  • lactiferous gland
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nuclear localization sequence binding
Cellular component
  • nuclear membrane
  • nuclear periphery
  • nucleus
  • cytoplasm
Biological process
  • protein transport
  • intracellular protein transport
  • ribosomal protein import into nucleus
  • NLS-bearing protein import into nucleus
  • protein import into nucleus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

30000

212999

Ensembl

ENSG00000105576

ENSMUSG00000031691

UniProt

O14787

Q99LG2

RefSeq (mRNA)

NM_013433
NM_001136195
NM_001136196

NM_001122843
NM_145390
NM_001364031
NM_001364032
NM_001364033

NM_001364034
NM_001379096

RefSeq (protein)
NP_001129667
NP_001129668
NP_038461
NP_001369165
NP_001369166

NP_001369167
NP_001369168
NP_001369169
NP_001369170
NP_001369171
NP_001369172
NP_001129667.1
NP_038461.2

NP_001116315
NP_663365
NP_001350960
NP_001350961
NP_001350962

NP_001350963
NP_001366025

Location (UCSC)Chr 19: 12.7 – 12.72 MbChr 8: 85.76 – 85.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transportin-2 is a protein that in humans is encoded by the TNPO2 gene.[5][6][7]

Interactions

TNPO2 has been shown to interact with NXF1,[6] NUP98[8] and Ran (biology).[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105576 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031691 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Siomi MC, Eder PS, Kataoka N, Wan L, Liu Q, Dreyfuss G (September 1997). "Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins". The Journal of Cell Biology. 138 (6): 1181–92. doi:10.1083/jcb.138.6.1181. PMC 2132560. PMID 9298975.
  6. ^ a b c Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proceedings of the National Academy of Sciences of the United States of America. 99 (22): 14195–9. Bibcode:2002PNAS...9914195S. doi:10.1073/pnas.212518199. PMC 137860. PMID 12384575.
  7. ^ "Entrez Gene: TNPO2 transportin 2 (importin 3, karyopherin beta 2b)".
  8. ^ Fontoura BM, Blobel G, Yaseen NR (October 2000). "The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import". The Journal of Biological Chemistry. 275 (40): 31289–96. doi:10.1074/jbc.M004651200. PMID 10875935.

Further reading

  • Gallouzi IE, Steitz JA (November 2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309. S2CID 43726887.
  • Blanc V, Kennedy S, Davidson NO (October 2003). "A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling". The Journal of Biological Chemistry. 278 (42): 41198–204. doi:10.1074/jbc.M302951200. PMID 12896982.
  • Güttinger S, Mühlhäusser P, Koller-Eichhorn R, Brennecke J, Kutay U (March 2004). "Transportin2 functions as importin and mediates nuclear import of HuR". Proceedings of the National Academy of Sciences of the United States of America. 101 (9): 2918–23. Bibcode:2004PNAS..101.2918G. doi:10.1073/pnas.0400342101. PMC 365720. PMID 14981248.
  • Rebane A, Aab A, Steitz JA (April 2004). "Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR". RNA. 10 (4): 590–9. doi:10.1261/rna.5224304. PMC 1370549. PMID 15037768.
  • Lee BJ, Cansizoglu AE, Süel KE, Louis TH, Zhang Z, Chook YM (August 2006). "Rules for nuclear localization sequence recognition by karyopherin beta 2". Cell. 126 (3): 543–58. doi:10.1016/j.cell.2006.05.049. PMC 3442361. PMID 16901787.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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