TJP3

Protein-coding gene in the species Homo sapiens
TJP3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3KFV

Identifiers
AliasesTJP3, ZO-3, ZO3, tight junction protein 3
External IDsOMIM: 612689; MGI: 1351650; HomoloGene: 8458; GeneCards: TJP3; OMA:TJP3 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for TJP3
Genomic location for TJP3
Band19p13.3Start3,708,362 bp[1]
End3,750,813 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for TJP3
Genomic location for TJP3
Band10|10 C1Start81,109,041 bp[2]
End81,127,415 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • right uterine tube

  • olfactory zone of nasal mucosa

  • left testis

  • right testis

  • nasal epithelium

  • buccal mucosa cell

  • epithelium of bronchus

  • bronchial epithelial cell

  • rectum
Top expressed in
  • crypt of lieberkuhn of small intestine

  • left colon

  • ileum

  • epithelium of stomach

  • jejunum

  • intestinal villus

  • duodenum

  • mucous cell of stomach

  • transitional epithelium of urinary bladder

  • pyloric antrum
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27134

27375

Ensembl

ENSG00000105289

ENSMUSG00000034917

UniProt

O95049

Q9QXY1

RefSeq (mRNA)

NM_014428
NM_001267560
NM_001267561

NM_001282095
NM_001282096
NM_013769

RefSeq (protein)

NP_001254489
NP_001254490

n/a

Location (UCSC)Chr 19: 3.71 – 3.75 MbChr 10: 81.11 – 81.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tight junction protein ZO-3 is a protein that in humans is encoded by the TJP3 gene.[5]

Interactions

TJP3 has been shown to interact with tight junction protein 1.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105289 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034917 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TJP3 tight junction protein 3 (zona occludens 3)".
  6. ^ Wittchen ES, Haskins J, Stevenson BR (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". The Journal of Biological Chemistry. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.

Further reading

  • Roh MH, Liu CJ, Laurinec S, Margolis B (July 2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions". The Journal of Biological Chemistry. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
  • Kausalya PJ, Reichert M, Hunziker W (September 2001). "Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells". FEBS Letters. 505 (1): 92–6. doi:10.1016/S0014-5793(01)02786-7. PMID 11557048. S2CID 13489358.
  • Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (December 1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". The Journal of Cell Biology. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
  • Wittchen ES, Haskins J, Stevenson BR (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". The Journal of Biological Chemistry. 274 (49): 35179–85. doi:10.1074/jbc.274.49.35179. PMID 10575001.
  • Haskins J, Gu L, Wittchen ES, Hibbard J, Stevenson BR (April 1998). "ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin". The Journal of Cell Biology. 141 (1): 199–208. doi:10.1083/jcb.141.1.199. PMC 2132714. PMID 9531559.


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