TIPARP

Protein-coding gene in the species Homo sapiens
TIPARP
Identifiers
AliasesTIPARP, ARTD14, PARP7, pART14, TCDD inducible poly(ADP-ribose) polymerase
External IDsOMIM: 612480; MGI: 2159210; HomoloGene: 9167; GeneCards: TIPARP; OMA:TIPARP - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TIPARP
Genomic location for TIPARP
Band3q25.31Start156,673,235 bp[1]
End156,706,770 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for TIPARP
Genomic location for TIPARP
Band3|3 E1Start65,435,831 bp[2]
End65,462,939 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • skin of thigh

  • vena cava

  • tail of epididymis

  • caput epididymis

  • Achilles tendon

  • mucosa of urinary bladder

  • mucosa of pharynx

  • urethra

  • palpebral conjunctiva
Top expressed in
  • zygote

  • secondary oocyte

  • primary oocyte

  • epithelium of lens

  • sciatic nerve

  • medial ganglionic eminence

  • spermatocyte

  • tail of embryo

  • transitional epithelium of urinary bladder

  • decidua
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • glycosyltransferase activity
  • metal ion binding
  • NAD+ ADP-ribosyltransferase activity
  • protein ADP-ribosylase activity
Cellular component
  • nucleus
Biological process
  • roof of mouth development
  • protein ADP-ribosylation
  • positive regulation of protein catabolic process
  • estrogen metabolic process
  • androgen metabolic process
  • kidney development
  • skeletal system morphogenesis
  • cellular response to organic cyclic compound
  • post-embryonic development
  • negative regulation of gene expression
  • female gonad development
  • vasculogenesis
  • nitrogen compound metabolic process
  • smooth muscle tissue development
  • platelet-derived growth factor receptor signaling pathway
  • face morphogenesis
  • hemopoiesis
  • response to 2,3,7,8-tetrachlorodibenzodioxine
  • protein auto-ADP-ribosylation
  • protein mono-ADP-ribosylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25976

99929

Ensembl

ENSG00000163659

ENSMUSG00000034640

UniProt

Q7Z3E1

Q8C1B2

RefSeq (mRNA)

NM_001184717
NM_001184718
NM_015508

NM_178892

RefSeq (protein)

NP_001171646
NP_001171647
NP_056323

NP_849223

Location (UCSC)Chr 3: 156.67 – 156.71 MbChr 3: 65.44 – 65.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TCDD-inducible poly [ADP-ribose] polymerase is an enzyme that in humans is encoded by the TIPARP gene.[5][6]

See also

  • TCDD, or 2,3,7,8-Tetrachlorodibenzodioxin

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163659 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034640 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7. doi:10.3892/ijo.23.2.541. PMID 12851707.
  6. ^ "Entrez Gene: TIPARP TCDD-inducible poly(ADP-ribose) polymerase".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Ménisser-de Murcia J, Mark M, Wendling O, et al. (2001). "Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development". Mol. Cell. Biol. 21 (5): 1828–32. doi:10.1128/MCB.21.5.1828-1832.2001. PMC 86747. PMID 11238919.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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