TCIM

Protein-coding gene in the species Homo sapiens
TCIM
Identifiers
AliasesTCIM, TC-1, TC1, C8orf4, chromosome 8 open reading frame 4, transcriptional and immune response regulator
External IDsOMIM: 607702; MGI: 1916318; HomoloGene: 10590; GeneCards: TCIM; OMA:TCIM - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for TCIM
Genomic location for TCIM
Band8p11.21Start40,153,482 bp[1]
End40,155,310 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for TCIM
Genomic location for TCIM
Band8|8 A2Start24,927,196 bp[2]
End24,929,000 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • parotid gland

  • gallbladder

  • right lung

  • vena cava

  • mucosa of urinary bladder

  • seminal vesicula

  • upper lobe of left lung

  • pericardium

  • visceral pleura

  • rectum
Top expressed in
  • parotid gland

  • lacrimal gland

  • left lung lobe

  • interventricular septum

  • seminal vesicula

  • molar

  • olfactory epithelium

  • epithelium of small intestine

  • intestinal villus

  • brown adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • Notch binding
Cellular component
  • cytoplasm
  • nuclear speck
  • nucleolus
  • nucleus
  • nucleoplasm
  • cytosol
  • plasma membrane
  • intracellular anatomical structure
Biological process
  • regulation of cell cycle G1/S phase transition
  • endothelial cell activation involved in immune response
  • cellular response to heat
  • regulation of DNA-templated transcription in response to stress
  • regulation of hemopoiesis
  • negative regulation of Notch signaling pathway
  • apoptotic process
  • positive regulation of protein kinase A signaling
  • negative regulation of apoptotic process
  • positive regulation of protein kinase C activity
  • positive regulation of NIK/NF-kappaB signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56892

69068

Ensembl

ENSG00000176907

ENSMUSG00000056313

UniProt

Q9NR00

Q9D915

RefSeq (mRNA)

NM_020130

NM_026931

RefSeq (protein)

NP_064515

NP_081207

Location (UCSC)Chr 8: 40.15 – 40.16 MbChr 8: 24.93 – 24.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TCIM is a protein that in humans is encoded by the TCIM gene.[5][6]

Function

This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39).[7] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176907 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056313 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chua EL, Young L, Wu WM, Turtle JR, Dong Q (November 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.
  6. ^ a b "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".
  7. ^ Kozlowski LP (October 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290.

Further reading

  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK (April 2004). "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer". Cancer Research. 64 (8): 2766–73. doi:10.1158/0008-5472.CAN-03-2093. PMID 15087392.
  • Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD (August 2004). "C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer". International Journal of Cancer. 111 (1): 72–5. doi:10.1002/ijc.20235. PMID 15185345. S2CID 19983783.
  • Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon RT, Song K, Lee I (January 2006). "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby" (PDF). Cancer Research. 66 (2): 723–8. doi:10.1158/0008-5472.CAN-05-3124. PMID 16424001.
  • Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, Kim J, Park J, Moon RT, Song K, Lee I (June 2006). "TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer". Clinical Cancer Research. 12 (11 Pt 1): 3541–8. doi:10.1158/1078-0432.CCR-05-2440. PMID 16740781.
  • Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP (December 2006). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer". Cancer Research. 66 (24): 11632–43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
  • Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP (September 2007). "Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways". International Journal of Cancer. 121 (6): 1265–73. doi:10.1002/ijc.22831. PMID 17520678. S2CID 25292320.
  • Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K, Lee I (August 2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response". Biochemical and Biophysical Research Communications. 360 (2): 447–52. doi:10.1016/j.bbrc.2007.06.077. PMID 17603013.
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