TAF12

Protein-coding gene in the species Homo sapiens

TAF12

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1H3O

Identifiers

Aliases

TAF12, TAF2J, TAFII20, TATA-box binding protein associated factor 12

External IDs

OMIM: 600773; MGI: 1913714; HomoloGene: 68477; GeneCards: TAF12; OMA:TAF12 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p35.3	Start	28,587,829 bp^[1]
Band	1p35.3	End	28,648,291 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D2.3	Start	132,001,686 bp^[2]
Band	4\|4 D2.3	End	132,023,077 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

monocyte

gastrocnemius muscle

testicle

Achilles tendon

muscle of thigh

granulocyte

apex of heart

right testis

left testis

Top expressed in

zygote

interventricular septum

granulocyte

muscle of thigh

right kidney

fetal liver hematopoietic progenitor cell

secondary oocyte

extraocular muscle

digastric muscle

morula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding DNA-binding transcription factor activity transcription coactivator activity transcription factor binding protein binding protein heterodimerization activity TBP-class protein binding histone acetyltransferase activity
Cellular component	transcription factor TFTC complex transcription factor TFIID complex nucleoplasm nucleus SAGA complex SLIK (SAGA-like) complex
Biological process	regulation of transcription, DNA-templated positive regulation of DNA-binding transcription factor activity transcription by RNA polymerase II transcription, DNA-templated DNA-templated transcription, initiation transcription initiation from RNA polymerase II promoter regulation of signal transduction by p53 class mediator RNA polymerase II preinitiation complex assembly histone H3 acetylation positive regulation of nucleic acid-templated transcription
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6883


66464

Ensembl


ENSG00000120656


ENSMUSG00000028899

UniProt


Q16514


Q8VE65

RefSeq (mRNA)


NM_001135218 NM_005644


NM_025579

RefSeq (protein)


NP_001128690 NP_005635


NP_079855

Location (UCSC)

Chr 1: 28.59 – 28.65 Mb

Chr 4: 132 – 132.02 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.^[5]^[6]

Function

Control of transcription by RNA polymerase II involves the basal transcription machinery, which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached, whereas others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.^[6]

Interactions

TAF12 has been shown to interact with TAF9^[7] and Transcription initiation protein SPT3 homolog.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120656 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028899 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mengus G, May M, Jacq X, Staub A, Tora L, Chambon P, Davidson I (May 1995). "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID". EMBO J. 14 (7): 1520–31. doi:10.1002/j.1460-2075.1995.tb07138.x. PMC 398239. PMID 7729427.
^ ^a ^b "Entrez Gene: TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa".
^ ^a ^b Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.

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Kashanchi F, Piras G, Radonovich MF, Duvall JF, Fattaey A, Chiang CM, Roeder RG, Brady JN (1994). "Direct interaction of human TFIID with the HIV-1 transactivator tat". Nature. 367 (6460): 295–9. Bibcode:1994Natur.367..295K. doi:10.1038/367295a0. PMID 8121496. S2CID 4362048.
Hoffmann A, Chiang CM, Oelgeschläger T, Xie X, Burley SK, Nakatani Y, Roeder RG (1996). "A histone octamer-like structure within TFIID". Nature. 380 (6572): 356–9. Bibcode:1996Natur.380..356H. doi:10.1038/380356a0. PMID 8598932. S2CID 4263436.
Choi BI, Bando M, Hasegawa S, Horikoshi M (1996). "Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histones H2B and H3". Gene. 169 (2): 263–7. doi:10.1016/0378-1119(95)00838-1. PMID 8647459.
Hoffmann A, Roeder RG (1996). "Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation". J. Biol. Chem. 271 (30): 18194–202. doi:10.1074/jbc.271.30.18194. PMID 8663456.
Wang Z, Morris GF, Rice AP, Xiong W, Morris CB (1996). "Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (2): 128–38. doi:10.1097/00042560-199606010-00005. PMID 8680883.
Pendergrast PS, Morrison D, Tansey WP, Hernandez N (1996). "Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly". J. Virol. 70 (8): 5025–34. doi:10.1128/JVI.70.8.5025-5034.1996. PMC 190456. PMID 8764009.
Kashanchi F, Khleif SN, Duvall JF, Sadaie MR, Radonovich MF, Cho M, Martin MA, Chen SY, Weinmann R, Brady JN (1996). "Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex". J. Virol. 70 (8): 5503–10. doi:10.1128/JVI.70.8.5503-5510.1996. PMC 190508. PMID 8764062.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
Tao Y, Guermah M, Martinez E, Oelgeschläger T, Hasegawa S, Takada R, Yamamoto T, Horikoshi M, Roeder RG (1997). "Specific interactions and potential functions of human TAFII100". J. Biol. Chem. 272 (10): 6714–21. doi:10.1074/jbc.272.10.6714. PMID 9045704.
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes". J. Biol. Chem. 272 (11): 6951–8. doi:10.1074/jbc.272.11.6951. PMID 9054383.
Dantonel JC, Murthy KG, Manley JL, Tora L (1997). "Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA". Nature. 389 (6649): 399–402. Bibcode:1997Natur.389..399D. doi:10.1038/38763. PMID 9311784. S2CID 4413324.
Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. S2CID 18942972.
Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (1998). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Mol. Cell. 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
Gangloff YG, Werten S, Romier C, Carré L, Poch O, Moras D, Davidson I (2000). "The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs". Mol. Cell. Biol. 20 (1): 340–51. doi:10.1128/MCB.20.1.340-351.2000. PMC 85089. PMID 10594036.
Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". EMBO J. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.

External links

Overview of all the structural information available in the PDB for UniProt: Q16514 (Transcription initiation factor TFIID subunit 12) at the PDBe-KB.

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