SPATA5

Protein-coding gene in humans
SPATA5
Identifiers
AliasesSPATA5, AFG2, SPAF, EHLMRS, spermatogenesis associated 5, NEDHSB
External IDsOMIM: 613940; MGI: 1927170; HomoloGene: 56920; GeneCards: SPATA5; OMA:SPATA5 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for SPATA5
Genomic location for SPATA5
Band4q28.1Start122,923,070 bp[1]
End123,319,433 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SPATA5
Genomic location for SPATA5
Band3|3 BStart37,474,045 bp[2]
End37,633,245 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • Achilles tendon

  • palpebral conjunctiva

  • gonad

  • testicle

  • bone marrow cells

  • ventricular zone

  • internal globus pallidus

  • sural nerve

  • epithelium of colon
Top expressed in
  • spermatocyte

  • primitive streak

  • seminiferous tubule

  • primary oocyte

  • spermatid

  • Gonadal ridge

  • genital tubercle

  • tail of embryo

  • epiblast

  • motor neuron
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • ATP binding
  • ATPase activity
  • hydrolase activity
Cellular component
  • cytoplasm
  • mitochondrion
Biological process
  • multicellular organism development
  • cell differentiation
  • brain development
  • spermatogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

166378

57815

Ensembl

ENSG00000145375

ENSMUSG00000027722

UniProt

Q8NB90

Q3UMC0

RefSeq (mRNA)

NM_145207
NM_001317799
NM_001345856

NM_001163511
NM_021343
NM_001310473

RefSeq (protein)

NP_001304728
NP_001332785
NP_660208

NP_001156983
NP_001297402
NP_067318

Location (UCSC)Chr 4: 122.92 – 123.32 MbChr 3: 37.47 – 37.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Spermatogenesis-associated protein 5 is a protein that in humans is encoded by the SPATA5 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145375 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027722 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh Y, Katoh M (Feb 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
  6. ^ "Entrez Gene: SPATA5 spermatogenesis associated 5".

Further reading

  • Liu Y, Black J, Kisiel N, Kulesz-Martin MF (2000). "SPAF, a new AAA-protein specific to early spermatogenesis and malignant conversion". Oncogene. 19 (12): 1579–88. doi:10.1038/sj.onc.1203442. PMID 10734318.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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