SPATA2

Protein-coding gene in humans
SPATA2
Identifiers
AliasesSPATA2, PD1, PPP1R145, tamo, spermatogenesis associated 2
External IDsOMIM: 607662; MGI: 2146885; HomoloGene: 4407; GeneCards: SPATA2; OMA:SPATA2 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for SPATA2
Genomic location for SPATA2
Band20q13.13Start49,903,391 bp[1]
End49,915,529 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SPATA2
Genomic location for SPATA2
Band2|2 H3Start167,323,053 bp[2]
End167,334,807 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • middle temporal gyrus

  • endothelial cell

  • Brodmann area 23

  • primary visual cortex

  • right frontal lobe

  • prefrontal cortex

  • Brodmann area 9

  • C1 segment

  • caudate nucleus
Top expressed in
  • otic vesicle

  • lobe of cerebellum

  • zygote

  • cerebellar vermis

  • dentate gyrus of hippocampal formation granule cell

  • subiculum

  • visual cortex

  • primary motor cortex

  • primary visual cortex

  • hippocampus proper
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • cytoplasm
  • nucleus
  • fibrillar center
Biological process
  • multicellular organism development
  • cell differentiation
  • spermatogenesis
  • regulation of tumor necrosis factor-mediated signaling pathway
  • regulation of inflammatory response
  • regulation of necroptotic process
  • protein K63-linked deubiquitination
  • protein linear deubiquitination
  • programmed cell death
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9825

263876

Ensembl

ENSG00000158480

ENSMUSG00000047030

UniProt

Q9UM82

Q8K004

RefSeq (mRNA)

NM_001135773
NM_006038

NM_170756
NM_001356523

RefSeq (protein)

NP_001129245
NP_006029

NP_001343452
NP_739562

Location (UCSC)Chr 20: 49.9 – 49.92 MbChr 2: 167.32 – 167.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Spermatogenesis-associated protein 2 is a protein that in humans is encoded by the SPATA2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158480 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047030 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SPATA2 spermatogenesis associated 2".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  • Graziotto R, Foresta C, Scannapieco P, et al. (1999). "cDNA cloning and characterization of PD1: a novel human testicular protein with different expressions in various testiculopathies". Exp. Cell Res. 248 (2): 620–6. doi:10.1006/excr.1999.4449. PMID 10222154.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Liliana Slongo M, Zotti L, Onisto M (2003). "Cloning and characterization of the promoter region of human spata2 (spermatogenesis-associated protein 2) gene". Biochim. Biophys. Acta. 1625 (2): 192–6. doi:10.1016/s0167-4781(02)00594-8. PMID 12531478.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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