Protein-coding gene in the species Homo sapiens
SOCS4 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | SOCS4, SOCS7, suppressor of cytokine signaling 4 |
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External IDs | OMIM: 616337; MGI: 1914546; HomoloGene: 15442; GeneCards: SOCS4; OMA:SOCS4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 14 (human)[1] |
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| Band | 14q22.3 | Start | 55,027,230 bp[1] |
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End | 55,049,489 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 14 (mouse)[2] |
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| Band | 14|14 C1 | Start | 47,514,388 bp[2] |
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End | 47,533,559 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - pancreatic epithelial cell
- tibia
- visceral pleura
- parietal pleura
- tail of epididymis
- germinal epithelium
- mucosa of ileum
- mucosa of paranasal sinus
- cardiac muscle tissue of right atrium
- tibialis anterior muscle
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| Top expressed in | - medial ganglionic eminence
- conjunctival fornix
- vestibular membrane of cochlear duct
- epithelium of small intestine
- carotid body
- atrioventricular valve
- lymph node
- trigeminal ganglion
- lumbar spinal ganglion
- hair follicle
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - protein kinase inhibitor activity
- protein binding
| Cellular component | - cytoplasm
- intracellular anatomical structure
| Biological process | - negative regulation of epidermal growth factor-activated receptor activity
- regulation of growth
- negative regulation of signal transduction
- intracellular signal transduction
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- cytokine-mediated signaling pathway
- negative regulation of receptor signaling pathway via JAK-STAT
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 14: 55.03 – 55.05 Mb | Chr 14: 47.51 – 47.53 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.[5]
Function
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000180008 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048379 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Suppressor of cytokine signaling 4 (SOCS4)