SNX3

Protein-coding gene in the species Homo sapiens

SNX3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2YPS, 2MXC

Identifiers

Aliases

SNX3, Grd19, MCOPS8, SDP3, sorting nexin 3

External IDs

OMIM: 605930; MGI: 1860188; HomoloGene: 36144; GeneCards: SNX3; OMA:SNX3 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q21	Start	108,211,222 bp^[1]
Band	6q21	End	108,261,246 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 B2\|10 22.89 cM	Start	42,378,026 bp^[2]
Band	10 B2\|10 22.89 cM	End	42,411,377 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

trabecular bone

middle temporal gyrus

visceral pleura

parietal pleura

endothelial cell

right ventricle

germinal epithelium

parotid gland

Epithelium of choroid plexus

Brodmann area 23

Top expressed in

lactiferous gland

CA3 field

pyloric antrum

yolk sac

fetal liver hematopoietic progenitor cell

calvaria

plantaris muscle

facial motor nucleus

perirhinal cortex

entorhinal cortex

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-5-phosphate binding protein binding phosphatidylinositol binding protein phosphatase binding lipid binding phosphatidylinositol phosphate binding
Cellular component	cytoplasm cytosol endosome early endosome membrane early phagosome retromer complex early endosome phagocytic vesicle extracellular exosome cytoplasmic vesicle clathrin-coated vesicle extrinsic component of membrane endosome membrane
Biological process	protein to membrane docking negative regulation of viral entry into host cell negative regulation of phagocytosis response to bacterium negative regulation of protein catabolic process negative regulation of early endosome to late endosome transport membrane invagination regulation of Wnt signaling pathway intralumenal vesicle formation negative regulation of protein transport positive regulation of neuron projection development protein transport Wnt signaling pathway protein deubiquitination transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8724


54198

Ensembl


ENSG00000112335


ENSMUSG00000019804

UniProt


O60493


O70492

RefSeq (mRNA)


NM_152828 NM_001300928 NM_001300929 NM_003795 NM_152827


NM_017472

RefSeq (protein)


NP_001287857 NP_001287858 NP_003786 NP_690040


n/a

Location (UCSC)

Chr 6: 108.21 – 108.26 Mb

Chr 10: 42.38 – 42.41 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.^[5]^[6]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112335 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019804 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
^ ^a ^b "Entrez Gene: SNX3 sorting nexin 3".

Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
Xu Y, Hortsman H, Seet L, et al. (2001). "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P". Nat. Cell Biol. 3 (7): 658–66. doi:10.1038/35083051. PMID 11433298. S2CID 32893219.
Vervoort VS, Viljoen D, Smart R, et al. (2003). "Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype". J. Med. Genet. 39 (12): 893–9. doi:10.1136/jmg.39.12.893. PMC 1757218. PMID 12471201.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Kumar RA, Everman DB, Morgan CT, et al. (2007). "Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes". BMC Med. Genet. 8: 48. doi:10.1186/1471-2350-8-48. PMC 1950490. PMID 17655765.