SIPA1L2

Protein-coding gene in the species Homo sapiens
SIPA1L2
Identifiers
AliasesSIPA1L2, SPAL2, signal induced proliferation associated 1 like 2, SPAR2
External IDsOMIM: 611609; MGI: 2676970; HomoloGene: 18956; GeneCards: SIPA1L2; OMA:SIPA1L2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SIPA1L2
Genomic location for SIPA1L2
Band1q42.2Start232,397,965 bp[1]
End232,630,571 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for SIPA1L2
Genomic location for SIPA1L2
Band8|8 E2Start126,144,802 bp[2]
End126,296,547 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • myocardium of left ventricle

  • cardiac muscle tissue of right atrium

  • pons

  • decidua

  • right ventricle

  • lateral nuclear group of thalamus

  • buccal mucosa cell

  • sural nerve

  • middle temporal gyrus

  • Pars compacta
Top expressed in
  • pontine nuclei

  • habenula

  • granulocyte

  • secondary oocyte

  • gastrula

  • endocardial cushion

  • dentate gyrus

  • medulla oblongata

  • lumbar subsegment of spinal cord

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • GTPase activator activity
Cellular component
  • cellular component
Biological process
  • positive regulation of GTPase activity
  • regulation of small GTPase mediated signal transduction
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57568

244668

Ensembl

ENSG00000116991

ENSMUSG00000001995

UniProt

Q9P2F8

Q80TE4

RefSeq (mRNA)

NM_020808
NM_001377488

NM_001081337
NM_001357372

RefSeq (protein)

NP_065859
NP_001364417

NP_001074806
NP_001344301

Location (UCSC)Chr 1: 232.4 – 232.63 MbChr 8: 126.14 – 126.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Signal-induced proliferation-associated 1-like protein 2 is a protein that in humans is encoded by the SIPA1L2 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116991 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001995 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SIPA1L2 signal-induced proliferation-associated 1 like 2".

Further reading

  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Commun. Mass Spectrom. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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