SIDT1

Protein-coding gene in the species Homo sapiens
SIDT1
Identifiers
AliasesSIDT1, B830021E24Rik, SID-1, SID1, SID1 transmembrane family member 1
External IDsOMIM: 606816; MGI: 2443155; HomoloGene: 41189; GeneCards: SIDT1; OMA:SIDT1 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SIDT1
Genomic location for SIDT1
Band3q13.2Start113,532,555 bp[1]
End113,629,575 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for SIDT1
Genomic location for SIDT1
Band16|16 B4Start44,060,543 bp[2]
End44,153,559 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • rectum

  • mucosa of sigmoid colon

  • granulocyte

  • right frontal lobe

  • tonsil

  • lymph node

  • spleen

  • gallbladder

  • dorsolateral prefrontal cortex
Top expressed in
  • primary visual cortex

  • superior frontal gyrus

  • lacrimal gland

  • dentate gyrus of hippocampal formation granule cell

  • primary motor cortex

  • parotid gland

  • zygote

  • cerebellar cortex

  • submandibular gland

  • hippocampus proper
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • RNA transmembrane transporter activity
  • RNA binding
  • double-stranded RNA binding
Cellular component
  • membrane
  • integral component of membrane
  • lysosome
  • plasma membrane
Biological process
  • dsRNA transport
  • RNA transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54847

320007

Ensembl

ENSG00000072858

ENSMUSG00000022696

UniProt

Q9NXL6

Q6AXF6

RefSeq (mRNA)
NM_001308350
NM_017699
NM_001322294
NM_001322295
NM_001322296

NM_001322297
NM_001322298
NM_001322299
NM_001322300

NM_001159419
NM_198034

RefSeq (protein)
NP_001295279
NP_001309223
NP_001309224
NP_001309225
NP_001309226

NP_001309227
NP_001309228
NP_001309229
NP_060169

NP_001152891
NP_932151

Location (UCSC)Chr 3: 113.53 – 113.63 MbChr 16: 44.06 – 44.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SID1 transmembrane family member 1 is a protein that in humans is encoded by the SIDT1 gene. [5]

Function

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072858 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022696 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SID1 transmembrane family member 1". Retrieved 2017-10-02.

Further reading

  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Elhassan MO, Christie J, Duxbury MS (2012). "Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance". J. Biol. Chem. 287 (8): 5267–77. doi:10.1074/jbc.M111.318865. PMC 3285307. PMID 22174421.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.