SH3BP5

Protein-coding gene in the species Homo sapiens
SH3BP5
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4H3B

Identifiers
AliasesSH3BP5, SAB, SH3BP-5, SH3 domain binding protein 5
External IDsOMIM: 605612; MGI: 1344391; HomoloGene: 23450; GeneCards: SH3BP5; OMA:SH3BP5 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SH3BP5
Genomic location for SH3BP5
Band3p25.1Start15,254,353 bp[1]
End15,341,368 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for SH3BP5
Genomic location for SH3BP5
Band14|14 BStart31,081,837 bp[2]
End31,158,035 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • germinal epithelium

  • trigeminal ganglion

  • pericardium

  • visceral pleura

  • secondary oocyte

  • adrenal cortex

  • tendon of biceps brachii

  • left adrenal cortex

  • spinal ganglia
Top expressed in
  • stroma of bone marrow

  • granulocyte

  • endothelial cell of lymphatic vessel

  • dentate gyrus of hippocampal formation granule cell

  • barrel cortex

  • sexually immature organism

  • mesenteric lymph nodes

  • endocardial cushion

  • atrioventricular valve

  • saccule
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein kinase inhibitor activity
  • protein binding
  • SH3 domain binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytoplasm
  • mitochondrion
  • nucleoplasm
  • nuclear body
  • cytoplasmic vesicle membrane
  • membrane
  • cytoplasmic vesicle
Biological process
  • signal transduction
  • negative regulation of protein tyrosine kinase activity
  • intracellular signal transduction
  • negative regulation of protein kinase activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9467

24056

Ensembl

ENSG00000131370

ENSMUSG00000021892

UniProt

O60239

Q9Z131

RefSeq (mRNA)

NM_001018009
NM_004844

NM_011894
NM_001347585

RefSeq (protein)

NP_001018009
NP_004835

NP_001334514
NP_036024
NP_001391515
NP_001391516
NP_001391517

NP_001391518

Location (UCSC)Chr 3: 15.25 – 15.34 MbChr 14: 31.08 – 31.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.[5][6][7]

Interactions

SH3BP5 has been shown to interact with Bruton's tyrosine kinase[5][6] and MAPK8.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131370 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021892 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Matsushita M, Yamadori T, Kato S, Takemoto Y, Inazawa J, Baba Y, et al. (April 1998). "Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)". Biochemical and Biophysical Research Communications. 245 (2): 337–343. doi:10.1006/bbrc.1998.8420. PMID 9571151.
  6. ^ a b Yamadori T, Baba Y, Matsushita M, Hashimoto S, Kurosaki M, Kurosaki T, et al. (May 1999). "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6341–6346. Bibcode:1999PNAS...96.6341Y. doi:10.1073/pnas.96.11.6341. PMC 26883. PMID 10339589.
  7. ^ "Entrez Gene: SH3BP5 SH3-domain binding protein 5 (BTK-associated)".
  8. ^ Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". The Biochemical Journal. 367 (Pt 3): 577–585. doi:10.1042/BJ20020553. PMC 1222945. PMID 12167088.

Further reading a

  • Win S, Than TA, Han D, Petrovic LM, Kaplowitz N (October 2011). "c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice". The Journal of Biological Chemistry. 286 (40): 35071–35078. doi:10.1074/jbc.M111.276089. PMC 3186406. PMID 21844199.
  • Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N (June 2015). "Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity". Journal of Hepatology. 62 (6): 1367–1374. doi:10.1016/j.jhep.2015.01.032. PMC 4439305. PMID 25666017.
  • Win S, Min RW, Zhang J, Kanel G, Wanken B, Chen Y, et al. (December 2021). "Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis". Hepatology. 74 (6): 3127–3145. doi:10.1002/hep.32083. PMC 8639630. PMID 34331779.
  • Baba Y, Matsushita M, Matsuda Y, Inazawa J, Yamadori T, Hashimoto S, et al. (2000). "Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 221–222. doi:10.1159/000015430. PMID 10702676. S2CID 41425074.
  • Wiltshire C, Matsushita M, Tsukada S, Gillespie DA, May GH (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". The Biochemical Journal. 367 (Pt 3): 577–585. doi:10.1042/BJ20020553. PMC 1222945. PMID 12167088.
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Court NW, Kuo I, Quigley O, Bogoyevitch MA (June 2004). "Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3". Biochemical and Biophysical Research Communications. 319 (1): 130–137. doi:10.1016/j.bbrc.2004.04.148. PMID 15158451.
  • Wiltshire C, Gillespie DA, May GH (December 2004). "Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein". Biochemical Society Transactions. 32 (Pt 6): 1075–1077. doi:10.1042/BST0321075. PMID 15506969.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.