SH2D2A

Protein-coding gene in the species Homo sapiens

SH2D2A

Identifiers

Aliases

SH2D2A, F2771, SCAP, TSAD, VRAP, SH2 domain containing 2A

External IDs

OMIM: 604514; MGI: 1351596; HomoloGene: 2958; GeneCards: SH2D2A; OMA:SH2D2A - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q23.1	Start	156,806,243 bp^[1]
Band	1q23.1	End	156,816,848 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 F1\|3 38.78 cM	Start	87,754,062 bp^[2]
Band	3 F1\|3 38.78 cM	End	87,763,029 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

testicle

blood

gonad

spleen

appendix

epithelium of colon

lymph node

apex of heart

upper lobe of left lung

Top expressed in

thymus

blood

embryo

mesenteric lymph nodes

spleen

subcutaneous adipose tissue

hematopoietic cell

granulocyte

jejunum

islet of Langerhans

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	SH3 domain binding protein binding
Cellular component	cytoplasm cytosol
Biological process	multicellular organism development cell differentiation vascular endothelial growth factor receptor signaling pathway cell population proliferation angiogenesis signal transduction positive regulation of signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9047


27371

Ensembl


ENSG00000027869


ENSMUSG00000028071

UniProt


Q9NP31


Q9QXK9

RefSeq (mRNA)


NM_001161441 NM_001161442 NM_001161443 NM_001161444 NM_003975


NM_001025571 NM_021309

RefSeq (protein)


NP_001154913 NP_001154914 NP_001154915 NP_001154916 NP_003966


NP_001020742 NP_067284

Location (UCSC)

Chr 1: 156.81 – 156.82 Mb

Chr 3: 87.75 – 87.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.^[5]^[6]

Interactions

SH2D2A has been shown to interact with MAP3K2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000027869 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028071 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spurkland A, Brinchmann JE, Markussen G, Pedeutour F, Munthe E, Lea T, Vartdal F, Aasheim HC (February 1998). "Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites". The Journal of Biological Chemistry. 273 (8): 4539–46. doi:10.1074/jbc.273.8.4539. PMID 9468509.
^ "Entrez Gene: SH2D2A SH2 domain protein 2A".
^ Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL (February 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". The Journal of Biological Chemistry. 276 (7): 5093–100. doi:10.1074/jbc.M003719200. PMID 11073940.

Marti F, Lapinski PE, King PD (March 2005). "The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man". Immunology Letters. 97 (2): 165–70. doi:10.1016/j.imlet.2004.10.019. PMID 15752554.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Choi YB, Kim CK, Yun Y (November 1999). "Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation". Journal of Immunology. 163 (10): 5242–9. doi:10.4049/jimmunol.163.10.5242. PMID 10553045. S2CID 12378851.
Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA (December 1999). "RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation". The Journal of Experimental Medicine. 190 (11): 1657–68. doi:10.1084/jem.190.11.1657. PMC 2195727. PMID 10587356.
Wu LW, Mayo LD, Dunbar JD, Kessler KM, Ozes ON, Warren RS, Donner DB (March 2000). "VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor". The Journal of Biological Chemistry. 275 (9): 6059–62. doi:10.1074/jbc.275.9.6059. PMID 10692392.
Dai KZ, Vergnaud G, Ando A, Inoko H, Spurkland A (March 2000). "The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1". Immunogenetics. 51 (3): 179–85. doi:10.1007/s002510050029. PMID 10752626. S2CID 37269923.
Smerdel A, Dai KZ, Lorentzen AR, Flatø B, Maslinski S, Thorsby E, Førre Ø, Spurkland A (June 2004). "Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene". Genes and Immunity. 5 (4): 310–2. doi:10.1038/sj.gene.6364093. PMID 15129233. S2CID 23995329.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Matsumoto T, Bohman S, Dixelius J, Berge T, Dimberg A, Magnusson P, Wang L, Wikner C, Qi JH, Wernstedt C, Wu J, Bruheim S, Mugishima H, Mukhopadhyay D, Spurkland A, Claesson-Welsh L (July 2005). "VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis". The EMBO Journal. 24 (13): 2342–53. doi:10.1038/sj.emboj.7600709. PMC 1173150. PMID 15962004.
Park D, Park I, Lee D, Choi YB, Lee H, Yun Y (June 2007). "The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration". Blood. 109 (12): 5122–8. doi:10.1182/blood-2005-10-061838. PMID 17327418.