RBM23

Protein-coding gene in the species Homo sapiens
RBM23
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2CQ4, 2DNZ

Identifiers
AliasesRBM23, CAPERbeta, RNPC4, PP239, RNA binding motif protein 23
External IDsHomoloGene: 56796; GeneCards: RBM23; OMA:RBM23 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for RBM23
Genomic location for RBM23
Band14q11.2Start22,893,204 bp[1]
End22,919,182 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • right uterine tube

  • left ovary

  • right lobe of thyroid gland

  • islet of Langerhans

  • body of uterus

  • ventricular zone

  • left lobe of thyroid gland

  • right ovary

  • monocyte
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
  • nucleic acid binding
  • mRNA binding
  • U1 snRNP binding
Cellular component
  • membrane
  • nucleus
  • cytoplasmic stress granule
  • ribonucleoprotein complex
Biological process
  • mRNA processing
  • 3'-UTR-mediated mRNA destabilization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55147

n/a

Ensembl

ENSG00000100461

n/a

UniProt

Q86U06

n/a

RefSeq (mRNA)
NM_001077351
NM_001077352
NM_001308044
NM_018107
NM_001352762

NM_001352763
NM_001352764
NM_001352765
NM_001352766

n/a

RefSeq (protein)
NP_001070819
NP_001070820
NP_001294973
NP_060577
NP_001339691

NP_001339692
NP_001339693
NP_001339694
NP_001339695

n/a

Location (UCSC)Chr 14: 22.89 – 22.92 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Probable RNA-binding protein 23 is a protein that in humans is encoded by the RBM23 gene.[3]

Function

This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100461 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: RBM23 RNA binding motif protein 23".

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (November 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O'Malley BW (February 2005). "Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta". Molecular Cell. 17 (3): 429–39. doi:10.1016/j.molcel.2004.12.025. PMID 15694343.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Overview of all the structural information available in the PDB for UniProt: Q86U06 (Probable RNA-binding protein 23) at the PDBe-KB.
  • v
  • t
  • e
  • 2cq4: solution structure of RNA binding domain in RNA binding motif protein 23
    2cq4: solution structure of RNA binding domain in RNA binding motif protein 23
  • 2dnz: Solution structure of the second RNA binding domain of RNA binding motif protein 23
    2dnz: Solution structure of the second RNA binding domain of RNA binding motif protein 23
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