RABIF

Protein-coding gene in the species Homo sapiens
RABIF
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1FWQ, 2FU5

Identifiers
AliasesRABIF, MSS4, RASGFR3, RASGRF3, RAB interacting factor
External IDsOMIM: 603417; MGI: 2138605; HomoloGene: 37702; GeneCards: RABIF; OMA:RABIF - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RABIF
Genomic location for RABIF
Band1q32.1Start202,878,282 bp[1]
End202,889,149 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for RABIF
Genomic location for RABIF
Band1|1 E4Start134,422,386 bp[2]
End134,436,512 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • hair follicle

  • Brodmann area 10

  • gingival epithelium

  • epithelium of esophagus

  • endothelial cell

  • amniotic fluid

  • gonad

  • testicle

  • pancreatic epithelial cell
Top expressed in
  • skin of external ear

  • interventricular septum

  • superior cervical ganglion

  • external carotid artery

  • dermis

  • granulocyte

  • anterior horn of spinal cord

  • pituitary gland

  • zygote

  • secondary oocyte
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • zinc ion binding
  • protein binding
  • metal ion binding
  • guanyl-nucleotide exchange factor activity
Cellular component
  • cytosol
  • membrane
Biological process
  • protein transport
  • small GTPase mediated signal transduction
  • membrane fusion
  • post-Golgi vesicle-mediated transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5877

98710

Ensembl

ENSG00000183155

ENSMUSG00000042229

UniProt

P47224

Q91X96

RefSeq (mRNA)

NM_002871

NM_145510

RefSeq (protein)

NP_002862

NP_663485

Location (UCSC)Chr 1: 202.88 – 202.89 MbChr 1: 134.42 – 134.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide exchange factor MSS4 is a protein that in humans is encoded by the RABIF gene.[5][6][7]

Function

The Sec4/Rab-related small GTP-binding proteins are involved in the regulation of intracellular vesicular transport. Mss4 stimulates GTP-GDP exchange in Sec4 and Rab and binds to a subset of genetically related Rab proteins.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183155 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042229 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Müller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Büchler M, Adler G, Gress TM (Mar 1998). "Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer". Genomics. 46 (3): 389–96. doi:10.1006/geno.1997.5049. PMID 9441742.
  6. ^ Yu H, Schreiber SL (Aug 1995). "Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4". Biochemistry. 34 (28): 9103–10. CiteSeerX 10.1.1.540.2153. doi:10.1021/bi00028a020. PMID 7619808.
  7. ^ a b "Entrez Gene: RABIF RAB interacting factor".

Further reading

  • Yu H, Schreiber SL (1995). "Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface". Nature. 376 (6543): 788–91. Bibcode:1995Natur.376..788Y. doi:10.1038/376788a0. PMID 7651540. S2CID 4368525.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Burton JL, Slepnev V, De Camilli PV (1997). "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4". J. Biol. Chem. 272 (6): 3663–8. doi:10.1074/jbc.272.6.3663. PMID 9013620.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, Paulsson M, Aumailley M (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2–3): 351–5. doi:10.1016/S0014-5793(99)00151-9. PMID 10094488.
  • Strick DJ, Francescutti DM, Zhao Y, Elferink LA (2002). "Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis". J. Biol. Chem. 277 (36): 32722–9. doi:10.1074/jbc.M205101200. PMID 12105226.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • v
  • t
  • e
  • 1fwq: SOLUTION STRUCTURE OF HUMAN MSS4, A GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB PROTEINS
    1fwq: SOLUTION STRUCTURE OF HUMAN MSS4, A GUANINE NUCLEOTIDE EXCHANGE FACTOR FOR RAB PROTEINS
  • 1hxr: CRYSTAL STRUCTURE OF MSS4 AT 1.65 ANGSTROMS
    1hxr: CRYSTAL STRUCTURE OF MSS4 AT 1.65 ANGSTROMS
  • 2fu5: structure of Rab8 in complex with MSS4
    2fu5: structure of Rab8 in complex with MSS4


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