RAB5C
Protein-coding gene in the species Homo sapiens
RAB5C | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | RAB5C, L1880, RAB5CL, RAB5L, RABL, member RAS oncogene family | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 604037; MGI: 105306; HomoloGene: 55533; GeneCards: RAB5C; OMA:RAB5C - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene.[5][6] RAB5C belongs to the Ras-related protein family.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000108774 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019173 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1–2): 137–9. doi:10.1159/000134325. PMID 8646882.
- ^ "Entrez Gene: RAB5C RAB5C, member RAS oncogene family".
Further reading
- Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472. PMID 7951316. S2CID 11075629.
- Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells". J. Biol. Chem. 273 (51): 33901–4. doi:10.1074/jbc.273.51.33901. PMID 9852039.
- Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
- Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate". Infect. Immun. 68 (5): 2671–84. doi:10.1128/IAI.68.5.2671-2684.2000. PMC 97474. PMID 10768959.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1". J. Biol. Chem. 278 (10): 8494–500. doi:10.1074/jbc.M211514200. PMID 12493736.
- Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt 20): 4159–68. doi:10.1242/jcs.00718. PMID 12972505. S2CID 18217293.
- Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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PDB gallery
- 1huq: 1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE)
- 1n6h: Crystal Structure of Human Rab5a
- 1n6i: Crystal Structure of Human Rab5a A30P mutant Complex with GDP
- 1n6k: Crystal Structure of Human Rab5a A30P mutant complex with GDP and aluminum fluoride
- 1n6l: Crystal Structure of Human Rab5a A30P mutant complex with GTP
- 1n6n: Crystal Structure of Human Rab5a A30R mutant complex with GppNHp
- 1n6o: Crystal Structure of Human Rab5a A30K mutant complex with GppNHp
- 1n6p: Crystal Structure of Human Rab5a A30E mutant complex with GppNHp
- 1n6r: Crystal Structure of Human Rab5a A30L mutant complex with GppNHp
- 1r2q: Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution
- 1tu3: Crystal Structure of Rab5 complex with Rabaptin5 C-terminal Domain
- 1tu4: Crystal Structure of Rab5-GDP Complex
- 1z07: GppNHp-Bound Rab5c G55Q mutant GTPase
- 1z0d: GDP-Bound Rab5c GTPase
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