PODXL2

Protein-coding gene in the species Homo sapiens
PODXL2
Identifiers
AliasesPODXL2, EG, PODLX2, podocalyxin like 2
External IDsOMIM: 616627; MGI: 2442488; HomoloGene: 9254; GeneCards: PODXL2; OMA:PODXL2 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PODXL2
Genomic location for PODXL2
Band3q21.3Start127,629,185 bp[1]
End127,672,802 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for PODXL2
Genomic location for PODXL2
Band6|6 D1Start88,842,558 bp[2]
End88,875,044 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • right hemisphere of cerebellum

  • anterior cingulate cortex

  • right frontal lobe

  • ventricular zone

  • C1 segment

  • anterior pituitary

  • prefrontal cortex

  • Brodmann area 9

  • nucleus accumbens
Top expressed in
  • dorsomedial hypothalamic nucleus

  • superior frontal gyrus

  • central gray substance of midbrain

  • primary visual cortex

  • suprachiasmatic nucleus

  • cerebellar cortex

  • neural layer of retina

  • dorsal tegmental nucleus

  • lateral hypothalamus

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • glycosaminoglycan binding
  • protein binding
Cellular component
  • integral component of membrane
  • integral component of plasma membrane
  • membrane
  • Golgi lumen
Biological process
  • leukocyte tethering or rolling
  • cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50512

319655

Ensembl

ENSG00000114631

ENSMUSG00000033152

UniProt

Q9NZ53

Q8CAE9

RefSeq (mRNA)

NM_015720

NM_176973
NM_001347327
NM_001364575

RefSeq (protein)

NP_056535

NP_001334256
NP_795947
NP_001351504
NP_001366146
NP_001366147

NP_001366148
NP_001366149
NP_001366150
NP_001366151
NP_001366152

Location (UCSC)Chr 3: 127.63 – 127.67 MbChr 6: 88.84 – 88.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Podocalyxin like 2 is a protein that in humans is encoded by the PODXL2 gene. [5]

Structure

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012].


Function

Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114631 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033152 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Podocalyxin like 2". Retrieved 2017-10-11.

Further reading

  • Fieger CB, Sassetti CM, Rosen SD (2003). "Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x". J. Biol. Chem. 278 (30): 27390–8. doi:10.1074/jbc.M304204200. PMID 12889478.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.