Protein-coding gene in the species Homo sapiens
PODXL2 |
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Identifiers |
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Aliases | PODXL2, EG, PODLX2, podocalyxin like 2 |
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External IDs | OMIM: 616627; MGI: 2442488; HomoloGene: 9254; GeneCards: PODXL2; OMA:PODXL2 - orthologs |
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Gene location (Human) |
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![Chromosome 3 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/300px-Ideogram_human_chromosome_3.svg.png) | Chr. | Chromosome 3 (human)[1] |
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| Band | 3q21.3 | Start | 127,629,185 bp[1] |
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End | 127,672,802 bp[1] |
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Gene location (Mouse) |
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![Chromosome 6 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_6.svg/260px-Ideogram_house_mouse_chromosome_6.svg.png) | Chr. | Chromosome 6 (mouse)[2] |
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| Band | 6|6 D1 | Start | 88,842,558 bp[2] |
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End | 88,875,044 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - ganglionic eminence
- right hemisphere of cerebellum
- anterior cingulate cortex
- right frontal lobe
- ventricular zone
- C1 segment
- anterior pituitary
- prefrontal cortex
- Brodmann area 9
- nucleus accumbens
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| Top expressed in | - dorsomedial hypothalamic nucleus
- superior frontal gyrus
- central gray substance of midbrain
- primary visual cortex
- suprachiasmatic nucleus
- cerebellar cortex
- neural layer of retina
- dorsal tegmental nucleus
- lateral hypothalamus
- dentate gyrus of hippocampal formation granule cell
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - glycosaminoglycan binding
- protein binding
| Cellular component | - integral component of membrane
- integral component of plasma membrane
- membrane
- Golgi lumen
| Biological process | - leukocyte tethering or rolling
- cell adhesion
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_176973 NM_001347327 NM_001364575 |
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RefSeq (protein) | | NP_001334256 NP_795947 NP_001351504 NP_001366146 NP_001366147
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NP_001366148 NP_001366149 NP_001366150 NP_001366151 NP_001366152 |
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Location (UCSC) | Chr 3: 127.63 – 127.67 Mb | Chr 6: 88.84 – 88.88 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Podocalyxin like 2 is a protein that in humans is encoded by the PODXL2 gene. [5]
Structure
This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012].
Function
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000114631 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033152 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Podocalyxin like 2". Retrieved 2017-10-11.
Further reading
- Fieger CB, Sassetti CM, Rosen SD (2003). "Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x". J. Biol. Chem. 278 (30): 27390–8. doi:10.1074/jbc.M304204200. PMID 12889478.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.