PELI1

Protein-coding gene in the species Homo sapiens
PELI1
Identifiers
AliasesPELI1, pellino E3 ubiquitin protein ligase 1
External IDsOMIM: 614797; MGI: 1914495; HomoloGene: 23243; GeneCards: PELI1; OMA:PELI1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PELI1
Genomic location for PELI1
Band2p14Start64,092,652 bp[1]
End64,144,420 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for PELI1
Genomic location for PELI1
Band11 A3.1|11 13.81 cMStart21,041,291 bp[2]
End21,100,323 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of paranasal sinus

  • cartilage tissue

  • mucosa of pharynx

  • amniotic fluid

  • skin of thigh

  • vena cava

  • oral cavity

  • human penis

  • bone marrow

  • epithelium of nasopharynx
Top expressed in
  • medial ganglionic eminence

  • blood

  • mesenteric lymph nodes

  • left lung lobe

  • transitional epithelium of urinary bladder

  • nucleus accumbens

  • skin of external ear

  • olfactory tubercle

  • Rostral migratory stream

  • anterior amygdaloid area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ubiquitin-protein transferase activity
  • protein binding
  • ubiquitin-ubiquitin ligase activity
  • protein serine/threonine kinase activity
  • transferase activity
  • ubiquitin protein ligase activity
Cellular component
  • cytosol
  • nucleus
Biological process
  • response to dsRNA
  • positive regulation of toll-like receptor 3 signaling pathway
  • positive regulation of cytokine production
  • protein polyubiquitination
  • negative regulation of T cell proliferation
  • response to lipopolysaccharide
  • positive regulation of B cell proliferation
  • protein ubiquitination
  • positive regulation of toll-like receptor 4 signaling pathway
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of B cell activation
  • negative regulation of NF-kappaB transcription factor activity
  • positive regulation of protein ubiquitination
  • negative regulation of T cell activation
  • protein phosphorylation
  • immune response
  • Toll signaling pathway
  • protein K48-linked ubiquitination
  • interleukin-1-mediated signaling pathway
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • negative regulation of necroptotic process
  • protein K63-linked ubiquitination
  • regulation of Toll signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57162

67245

Ensembl

ENSG00000197329

ENSMUSG00000020134

UniProt

Q96FA3

Q8C669

RefSeq (mRNA)

NM_020651

NM_023324

RefSeq (protein)

NP_065702

NP_075813

Location (UCSC)Chr 2: 64.09 – 64.14 MbChr 11: 21.04 – 21.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein pellino homolog 1 is a protein that in humans is encoded by the PELI1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000197329 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020134 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Resch K, Jockusch H, Schmitt-John T (Apr 2001). "Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 172–174. doi:10.1159/000056895. PMID 11306823. S2CID 83911010.
  6. ^ Choi KC, Lee YS, Lim S, Choi HK, Lee CH, Lee EK, Hong S, Kim IH, Kim SJ, Park SH (Sep 2006). "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1". Nat Immunol. 7 (10): 1057–1065. doi:10.1038/ni1383. PMID 16951688. S2CID 9646386.
  7. ^ "Entrez Gene: PELI1 pellino homolog 1 (Drosophila)".

Further reading

  • Rich T, Allen RL, Lucas AM, et al. (2001). "Pellino-related sequences from Caenorhabditis elegans and Homo sapiens". Immunogenetics. 52 (1–2): 145–149. doi:10.1007/s002510000249. PMID 11132151. S2CID 13467302.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jiang Z, Johnson HJ, Nie H, et al. (2003). "Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex". J. Biol. Chem. 278 (13): 10952–10956. doi:10.1074/jbc.M212112200. PMID 12496252.
  • Jensen LE, Whitehead AS (2003). "Pellino2 activates the mitogen activated protein kinase pathway". FEBS Lett. 545 (2–3): 199–202. doi:10.1016/S0014-5793(03)00533-7. PMID 12804775. S2CID 46719284.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Butler MP, Hanly JA, Moynagh PN (2005). "Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner" (PDF). J. Biol. Chem. 280 (30): 27759–27768. doi:10.1074/jbc.M500756200. PMID 15917247. S2CID 30374239.
  • Butler MP, Hanly JA, Moynagh PN (2007). "Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases". J. Biol. Chem. 282 (41): 29729–29737. doi:10.1074/jbc.M704558200. PMID 17675297.


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