PDS5A

Protein-coding gene in the species Homo sapiens
PDS5A
Identifiers
AliasesPDS5A, SCC-112, SCC112, PIG54, PDS5 cohesin associated factor A
External IDsOMIM: 613200; MGI: 1918771; HomoloGene: 22877; GeneCards: PDS5A; OMA:PDS5A - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for PDS5A
Genomic location for PDS5A
Band4p14Start39,822,863 bp[1]
End39,977,956 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for PDS5A
Genomic location for PDS5A
Band5|5 C3.1Start65,763,064 bp[2]
End65,855,616 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • epithelium of nasopharynx

  • Achilles tendon

  • tonsil

  • gingival epithelium

  • epithelium of colon

  • Epithelium of choroid plexus

  • cartilage tissue

  • seminal vesicula

  • bone marrow cells
Top expressed in
  • tail of embryo

  • genital tubercle

  • ventricular zone

  • epiblast

  • primitive streak

  • thymus

  • lacrimal gland

  • cumulus cell

  • renal corpuscle

  • Paneth cell
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytosol
  • chromatin
  • plasma membrane
  • chromosome, centromeric region
  • nucleoplasm
  • chromosome
  • nucleus
Biological process
  • cell division
  • cell cycle
  • negative regulation of DNA replication
  • mitotic sister chromatid cohesion
  • DNA repair
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23244

71521

Ensembl

ENSG00000121892

ENSMUSG00000029202

UniProt

Q29RF7

Q6A026

RefSeq (mRNA)

NM_001100399
NM_001100400
NM_015200

NM_001081321
NM_027818

RefSeq (protein)

NP_001093869
NP_001093870

n/a

Location (UCSC)Chr 4: 39.82 – 39.98 MbChr 5: 65.76 – 65.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121892 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029202 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (Dec 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  6. ^ Losada A, Yokochi T, Hirano T (May 2005). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts". J Cell Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230.
  7. ^ "Entrez Gene: SCC-112 SCC-112 protein".

Further reading

  • Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kumar D, Sakabe I, Patel S, et al. (2004). "SCC-112, a novel cell cycle-regulated molecule, exhibits reduced expression in human renal carcinomas". Gene. 328: 187–96. doi:10.1016/j.gene.2003.12.013. PMID 15019998.
  • Rankin S, Ayad NG, Kirschner MW (2005). "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates". Mol. Cell. 18 (2): 185–200. doi:10.1016/j.molcel.2005.03.017. PMID 15837422.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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