PDLIM4

Protein-coding gene in the species Homo sapiens
PDLIM4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2EEG, 2V1W, 4Q2O

Identifiers
AliasesPDLIM4, RIL, PDZ and LIM domain 4
External IDsOMIM: 603422; MGI: 1353470; HomoloGene: 2735; GeneCards: PDLIM4; OMA:PDLIM4 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for PDLIM4
Genomic location for PDLIM4
Band5q31.1Start132,257,696 bp[1]
End132,273,454 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for PDLIM4
Genomic location for PDLIM4
Band11 B1.3|11 32.13 cMStart53,945,754 bp[2]
End53,959,840 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left uterine tube

  • body of uterus

  • tibial nerve

  • muscle layer of sigmoid colon

  • cartilage tissue

  • skin of leg

  • gastric mucosa

  • skin of abdomen

  • ascending aorta

  • Descending thoracic aorta
Top expressed in
  • lip

  • body wall

  • condyle

  • uterus

  • epithelium of stomach

  • stroma of bone marrow

  • calvaria

  • ankle joint

  • molar

  • cervix
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • protein binding
  • protein phosphatase binding
  • protein homodimerization activity
  • alpha-actinin binding
  • actin binding
  • muscle alpha-actinin binding
Cellular component
  • stress fiber
  • early endosome lumen
  • filamentous actin
  • recycling endosome lumen
  • postsynaptic membrane
  • nucleus
  • cytoplasm
  • endosome
  • cytoskeleton
  • membrane
  • lamellipodium
  • cell junction
  • early endosome membrane
  • cell projection
  • neuron projection
  • dendritic spine
  • synapse
  • perinuclear region of cytoplasm
  • recycling endosome membrane
  • Z disc
Biological process
  • actin cytoskeleton reorganization
  • excitatory chemical synaptic transmission
  • heart development
  • actin cytoskeleton organization
  • muscle structure development
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8572

30794

Ensembl

ENSG00000131435

ENSMUSG00000020388

UniProt

P50479

P70271

RefSeq (mRNA)

NM_003687
NM_001131027

NM_019417

RefSeq (protein)

NP_001124499
NP_003678

NP_062290

Location (UCSC)Chr 5: 132.26 – 132.27 MbChr 11: 53.95 – 53.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131435 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020388 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bashirova AA, Markelov ML, Shlykova TV, Levshenkova EV, Alibaeva RA, Frolova EI (Jun 1998). "The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts". Gene. 210 (2): 239–45. doi:10.1016/S0378-1119(98)00080-8. PMID 9573374.
  6. ^ "Entrez Gene: PDLIM4 PDZ and LIM domain 4".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Cuppen E, van Ham M, Wansink DG, et al. (2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". Eur. J. Cell Biol. 79 (4): 283–93. doi:10.1078/S0171-9335(04)70031-X. PMID 10826496.
  • Walma T, Spronk CA, Tessari M, et al. (2002). "Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL". J. Mol. Biol. 316 (5): 1101–10. doi:10.1006/jmbi.2002.5402. hdl:2066/187660. PMID 11884147.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Omasu F, Ezura Y, Kajita M, et al. (2003). "Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women". J. Hum. Genet. 48 (7): 342–5. doi:10.1007/s10038-003-0035-1. PMID 12908099.
  • Vallenius T, Scharm B, Vesikansa A, et al. (2004). "The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin". Exp. Cell Res. 293 (1): 117–28. doi:10.1016/j.yexcr.2003.09.004. PMID 14729062.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • van den Berk LC, van Ham MA, te Lindert MM, et al. (2005). "The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain". Mol. Biol. Rep. 31 (4): 203–15. doi:10.1007/s11033-005-1407-8. PMID 15663004. S2CID 21554968.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Schwartz LM, Woloshin S, Birkmeyer JD (2005). "How do elderly patients decide where to go for major surgery? Telephone interview survey". BMJ. 331 (7520): 821. doi:10.1136/bmj.38614.449016.DE. PMC 1246083. PMID 16192286.
  • Boumber YA, Kondo Y, Chen X, et al. (2007). "RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis". Cancer Res. 67 (5): 1997–2005. doi:10.1158/0008-5472.CAN-06-3093. PMID 17332327.


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