PDLIM2

Protein-coding gene in the species Homo sapiens

PDLIM2

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2PA1, 3PDV

Identifiers

Aliases

PDLIM2, MYSTIQUE, SLIM, PDZ and LIM domain 2

External IDs

OMIM: 609722; MGI: 2384850; HomoloGene: 11006; GeneCards: PDLIM2; OMA:PDLIM2 - orthologs

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8p21.3	Start	22,578,279 bp^[1]
Band	8p21.3	End	22,598,025 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 D2	Start	70,401,667 bp^[2]
Band	14\|14 D2	End	70,415,130 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

spleen

mucosa of pharynx

skin of leg

ascending aorta

skin of abdomen

Descending thoracic aorta

right coronary artery

stromal cell of endometrium

nipple

tibial nerve

Top expressed in

esophagus

granulocyte

right lung

intestinal villus

right lung lobe

calvaria

primary oocyte

left lung

left lung lobe

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding actin binding muscle alpha-actinin binding
Cellular component	cytoplasm cytoskeleton nucleus stress fiber Z disc filamentous actin
Biological process	heart development actin cytoskeleton organization muscle structure development
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64236


213019

Ensembl


ENSG00000120913


ENSMUSG00000022090

UniProt


Q96JY6


Q8R1G6

RefSeq (mRNA)


NM_198042 NM_021630 NM_176871 NM_001368120


NM_001253736 NM_145978

RefSeq (protein)


NP_067643 NP_789847 NP_932159 NP_001355049


NP_001240665 NP_666090

Location (UCSC)

Chr 8: 22.58 – 22.6 Mb

Chr 14: 70.4 – 70.42 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

PDZ and LIM domain protein 2 is a protein that in humans is encoded by the PDLIM2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120913 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022090 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PDLIM2 PDZ and LIM domain 2 (mystique)".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Loughran G, Healy NC, Kiely PA, et al. (2005). "Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth". Mol. Biol. Cell. 16 (4): 1811–22. doi:10.1091/mbc.E04-12-1052. PMC 1073663. PMID 15659642.
Tanaka T, Grusby MJ, Kaisho T (2007). "PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit". Nat. Immunol. 8 (6): 584–91. doi:10.1038/ni1464. PMID 17468759. S2CID 13357628.