PCID2

Protein-coding gene in the species Homo sapiens
PCID2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3T5X

Identifiers
AliasesPCID2, F10, PCI domain containing 2
External IDsOMIM: 613713; MGI: 2443003; HomoloGene: 10168; GeneCards: PCID2; OMA:PCID2 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for PCID2
Genomic location for PCID2
Band13q34Start113,177,536 bp[1]
End113,208,715 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for PCID2
Genomic location for PCID2
Band8|8 A1.1Start13,127,189 bp[2]
End13,155,459 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • left ovary

  • right ovary

  • left testis

  • right testis

  • canal of the cervix

  • body of uterus

  • cerebellar hemisphere

  • right hemisphere of cerebellum
Top expressed in
  • Ileal epithelium

  • perirhinal cortex

  • entorhinal cortex

  • choroid plexus of fourth ventricle

  • lactiferous gland

  • otic placode

  • CA3 field

  • otic vesicle

  • saccule

  • internal carotid artery
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • double-stranded DNA binding
  • RNA binding
Cellular component
  • nuclear pore
  • transcription export complex 2
  • cellular component
  • nucleus
  • cytoplasm
  • nuclear pore nuclear basket
Biological process
  • positive regulation of B cell differentiation
  • positive regulation of transcription, DNA-templated
  • positive regulation of mitotic cell cycle spindle assembly checkpoint
  • negative regulation of apoptotic process
  • spleen development
  • regulation of mRNA stability
  • negative regulation of cysteine-type endopeptidase activity
  • posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
  • transcription elongation from RNA polymerase II promoter
  • poly(A)+ mRNA export from nucleus
  • protein transport
  • mRNA transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55795

234069

Ensembl

ENSG00000126226

ENSMUSG00000038542

UniProt

Q5JVF3

Q8BFV2

RefSeq (mRNA)
NM_001127202
NM_001127203
NM_001258212
NM_001258213
NM_018386

NM_001320655
NM_001320656
NM_001320657
NM_001320659
NM_001320660
NM_001353091
NM_001353092
NM_001353093
NM_001353094
NM_001353095

NM_178708

RefSeq (protein)
NP_001120674
NP_001120675
NP_001245142
NP_001307584
NP_001307585

NP_001307586
NP_001307588
NP_001307589
NP_060856
NP_001340020
NP_001340021
NP_001340022
NP_001340023
NP_001340024

NP_848823

Location (UCSC)Chr 13: 113.18 – 113.21 MbChr 8: 13.13 – 13.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PCI domain containing 2 is a protein that in humans is encoded by the PCID2 gene. [5]

Function

This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126226 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038542 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PCI domain containing 2". Retrieved 2017-12-13.

Further reading

  • Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
  • Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z (2014). "Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of EID1 stability". Stem Cells. 32 (3): 623–35. doi:10.1002/stem.1580. PMID 24167073.


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.