OTUD1

Protein-coding gene in the species Homo sapiens
OTUD1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4BOP

Identifiers
AliasesOTUD1, DUBA7, OTDC1, OTU deubiquitinase 1
External IDsOMIM: 612022; MGI: 1918448; HomoloGene: 45953; GeneCards: OTUD1; OMA:OTUD1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for OTUD1
Genomic location for OTUD1
Band10p12.2Start23,439,075 bp[1]
End23,442,377 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for OTUD1
Genomic location for OTUD1
Band2|2 A3Start19,662,563 bp[2]
End19,665,394 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • Skeletal muscle tissue of rectus abdominis

  • myocardium of left ventricle

  • cardiac muscle tissue of right atrium

  • skin of arm

  • tibialis anterior muscle

  • amniotic fluid

  • muscle of thigh

  • skin of thigh

  • vena cava
Top expressed in
  • ascending aorta

  • aortic valve

  • soleus muscle

  • tibialis anterior muscle

  • quadriceps femoris muscle

  • thoracic diaphragm

  • muscle of thigh

  • secondary oocyte

  • digastric muscle

  • ankle
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

220213

71198

Ensembl

ENSG00000165312

ENSMUSG00000043415

UniProt

Q5VV17

Q9CUB6

RefSeq (mRNA)

NM_001145373

NM_027715

RefSeq (protein)

NP_001138845

NP_081991

Location (UCSC)Chr 10: 23.44 – 23.44 MbChr 2: 19.66 – 19.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

OTU deubiquitinase 1 is a protein that in humans is encoded by the OTUD1 gene. [5]

Function

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA7 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165312 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043415 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: OTU deubiquitinase 1". Retrieved 2016-03-13.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human OTU domain-containing protein 1

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e