MFSD5

Protein-coding gene in the species Homo sapiens
MFSD5
Identifiers
AliasesMFSD5, hsMOT2, major facilitator superfamily domain containing 5, SLC61A1
External IDsMGI: 2145901; HomoloGene: 69517; GeneCards: MFSD5; OMA:MFSD5 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for MFSD5
Genomic location for MFSD5
Band12q13.13Start53,251,251 bp[1]
End53,254,406 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for MFSD5
Genomic location for MFSD5
Band15|15 F2Start102,187,889 bp[2]
End102,190,189 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of leg

  • skin of abdomen

  • mucosa of transverse colon

  • right adrenal cortex

  • granulocyte

  • left adrenal gland

  • left adrenal cortex

  • gums

  • gingival epithelium

  • apex of heart
Top expressed in
  • lip

  • stroma of bone marrow

  • transitional epithelium of urinary bladder

  • esophagus

  • right kidney

  • skin of external ear

  • calvaria

  • yolk sac

  • choroid plexus of fourth ventricle

  • granulocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • molybdate ion transmembrane transporter activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • molybdate ion transport
  • ion transport
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84975

106073

Ensembl

ENSG00000182544

ENSMUSG00000045665

UniProt

Q6N075

Q921Y4

RefSeq (mRNA)

NM_001170790
NM_032889

NM_134100

RefSeq (protein)

NP_001164261
NP_116278

NP_598861

Location (UCSC)Chr 12: 53.25 – 53.25 MbChr 15: 102.19 – 102.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Major facilitator superfamily domain containing 5 is an atypical SLC expressed in neuronal plasma membrane.[5] It is a plausible Solute carrier transporter.[6] It transports molybdate anions,[7] and it interacts with GLP-1R.[8]

MFSD5 belongs to AMTF6.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182544 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045665 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
  6. ^ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  7. ^ Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.
  8. ^ Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.
  9. ^ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
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