Maduropeptin

Chemical complex
(−)-Maduropeptin chromophore C-5 methanol adduct

Maduropeptin consists of a 1:1 complex of a carrier protein (MdpA) and a chromophore isolated from Actinomadura madurae.[1] The chromophore has an enediyne structure and is an antibiotic with anticancer activity.[citation needed]

References

  1. ^ Ling, J; Horsman, G. P; Huang, S. X; Luo, Y; Lin, S; Shen, B (2010). "Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate". Journal of the American Chemical Society. 132 (36): 12534–6. doi:10.1021/ja1050814. PMC 2935939. PMID 20718468.
  • Maduropeptin chromophore at ChemSpider
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Enediynes
9 membered rings
  • C-1027
  • Kedarcidin
  • Maduropeptin
  • Neocarzinostatin
10 membered rings
  • Calicheamicin
  • Dynemicin A
  • Esperamicin
  • Golfomycin A
  • Shishijimicin A
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