MPHOSPH10

Protein-coding gene in the species Homo sapiens
MPHOSPH10
Identifiers
AliasesMPHOSPH10, CT90, MPP10, MPP10P, PPP1R106, M-phase phosphoprotein 10
External IDsOMIM: 605503; MGI: 1915223; HomoloGene: 134741; GeneCards: MPHOSPH10; OMA:MPHOSPH10 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for MPHOSPH10
Genomic location for MPHOSPH10
Band2p13.3Start71,130,310 bp[1]
End71,150,101 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for MPHOSPH10
Genomic location for MPHOSPH10
Band7|7 CStart64,026,275 bp[2]
End64,042,016 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • tendon of biceps brachii

  • endometrium

  • mucosa of esophagus

  • oral cavity

  • Pars compacta

  • glutes

  • pericardium

  • hair follicle

  • mucosa of pharynx
Top expressed in
  • genital tubercle

  • zygote

  • tail of embryo

  • secondary oocyte

  • primary oocyte

  • epiblast

  • primitive streak

  • fetal liver hematopoietic progenitor cell

  • morula

  • morula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • RNA binding
Cellular component
  • sno(s)RNA-containing ribonucleoprotein complex
  • small-subunit processome
  • Mpp10 complex
  • nucleolus
  • nucleus
  • chromosome
  • nucleoplasm
Biological process
  • RNA splicing, via transesterification reactions
  • negative regulation of phosphatase activity
  • RNA processing
  • ribosome biogenesis
  • RNA splicing
  • rRNA processing
  • maturation of SSU-rRNA
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10199

67973

Ensembl

ENSG00000124383

ENSMUSG00000030521

UniProt

O00566

Q810V0

RefSeq (mRNA)

NM_005791

NM_026483

RefSeq (protein)

NP_005782

NP_080759

Location (UCSC)Chr 2: 71.13 – 71.15 MbChr 7: 64.03 – 64.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U3 small nucleolar ribonucleoprotein protein MPP10 is a protein that in humans is encoded by the MPHOSPH10 gene.[5][6][7]

This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein is thought to be part of the U3 small nucleolar ribonucleoprotein complex, which is involved in rRNA processing.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124383 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030521 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
  6. ^ Westendorf JM, Konstantinov KN, Wormsley S, Shu MD, Matsumoto-Taniura N, Pirollet F, Klier FG, Gerace L, Baserga SJ (Mar 1998). "M Phase Phosphoprotein 10 Is a Human U3 Small Nucleolar Ribonucleoprotein Component". Mol Biol Cell. 9 (2): 437–49. doi:10.1091/mbc.9.2.437. PMC 25272. PMID 9450966.
  7. ^ a b "Entrez Gene: MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)".

Further reading

  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Granneman S, Gallagher JE, Vogelzangs J, et al. (2003). "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60–80S ribonucleoprotein complexes". Nucleic Acids Res. 31 (7): 1877–87. doi:10.1093/nar/gkg300. PMC 152815. PMID 12655004.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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