Protein-coding gene in the species Homo sapiens
MOB1B |
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Identifiers |
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Aliases | MOB1B, MATS2, MOB4A, MOBKL1A, MOB kinase activator 1B |
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External IDs | OMIM: 609282; MGI: 1915723; HomoloGene: 61676; GeneCards: MOB1B; OMA:MOB1B - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4q13.3 | Start | 70,902,326 bp[1] |
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End | 71,022,449 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 5 (mouse)[2] |
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| Band | 5|5 E1 | Start | 88,868,714 bp[2] |
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End | 88,912,079 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - renal medulla
- thymus
- superior surface of tongue
- saphenous vein
- skin of arm
- trabecular bone
- medulla oblongata
- trigeminal ganglion
- superior vestibular nucleus
- body of tongue
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| Top expressed in | - superior surface of tongue
- gallbladder
- seminal vesicula
- Epithelium of choroid plexus
- left lobe of liver
- aortic valve
- ascending aorta
- ciliary body
- atrioventricular valve
- epithelium of stomach
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - kinase binding
- protein binding
- kinase activator activity
- metal ion binding
| Cellular component | - cytoplasm
- extracellular exosome
- nucleus
- nucleolus
- cytosol
| Biological process | - regulation of protein autophosphorylation
- hippo signaling
- positive regulation of phosphorylation
- positive regulation of kinase activity
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001244766 NM_001244767 NM_173468 |
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RefSeq (protein) | |
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NP_001231695 NP_001231696 NP_775739 |
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Location (UCSC) | Chr 4: 70.9 – 71.02 Mb | Chr 5: 88.87 – 88.91 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Mps one binder kinase activator-like 1A, also known as Mob1 homolog 1A, is a protein that in humans is encoded by the MOBKL1A gene.[5][6]
Function
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation.[5]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000173542 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006262 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: MOB1".
- ^ Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (June 2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.
Further reading
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chow A, Hao Y, Yang X (2010). "Molecular characterization of human homologs of yeast MOB1". Int. J. Cancer. 126 (9): 2079–89. doi:10.1002/ijc.24878. hdl:1974/1468. PMID 19739119. S2CID 33688672.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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