MARC2

Protein-coding gene in the species Homo sapiens
MTARC2
Identifiers
AliasesMTARC2, MOSC2, mitochondrial amidoxime reducing component 2, MARC2
External IDsOMIM: 614127; MGI: 1914497; HomoloGene: 9904; GeneCards: MTARC2; OMA:MTARC2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MTARC2
Genomic location for MTARC2
Band1q41Start220,748,225 bp[1]
End220,784,815 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for MTARC2
Genomic location for MTARC2
Band1|1 H5Start184,545,265 bp[2]
End184,578,648 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • right lung

  • kidney tubule

  • duodenum

  • parotid gland

  • body of pancreas

  • jejunal mucosa

  • human kidney
Top expressed in
  • duodenum

  • left lobe of liver

  • jejunum

  • right kidney

  • parotid gland

  • lacrimal gland

  • gallbladder

  • proximal tubule

  • human kidney

  • submandibular gland
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • molybdopterin cofactor binding
  • molybdenum ion binding
  • oxidoreductase activity
  • pyridoxal phosphate binding
  • nitrate reductase activity
  • catalytic activity
Cellular component
  • peroxisome
  • mitochondrion
  • membrane
  • mitochondrial outer membrane
Biological process
  • detoxification of nitrogen compound
  • nitrate metabolic process
  • xenobiotic metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54996

67247

Ensembl

ENSG00000117791

ENSMUSG00000073481

UniProt

Q969Z3

Q922Q1

RefSeq (mRNA)

NM_017898
NM_001317338
NM_001331042

NM_133684
NM_001368285
NM_001368286

RefSeq (protein)

NP_001304267
NP_001317971
NP_060368

NP_598445
NP_001355214
NP_001355215

Location (UCSC)Chr 1: 220.75 – 220.78 MbChr 1: 184.55 – 184.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MOSC domain-containing protein 2, mitochondrial is a protein that in humans is encoded by the MOSC2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117791 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073481 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Anantharaman V, Aravind L (Mar 2002). "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases". FEMS Microbiol Lett. 207 (1): 55–61. doi:10.1016/S0378-1097(01)00515-8. PMID 11886751.
  6. ^ "Entrez Gene: MOSC2 MOCO sulphurase C-terminal domain containing 2".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Havemeyer A, Bittner F, Wollers S, et al. (2007). "Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme". J. Biol. Chem. 281 (46): 34796–802. doi:10.1074/jbc.M607697200. PMID 16973608.


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