LSM8

Protein-coding gene in the species Homo sapiens
LSM8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3JCR

Identifiers
AliasesLSM8, NAA38, LSM8 homolog, U6 small nuclear RNA associated
External IDsOMIM: 607288; MGI: 1923772; HomoloGene: 9419; GeneCards: LSM8; OMA:LSM8 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for LSM8
Genomic location for LSM8
Band7q31.31Start118,184,144 bp[1]
End118,204,035 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for LSM8
Genomic location for LSM8
Band6|6 A2Start18,848,578 bp[2]
End18,855,750 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • epithelium of colon

  • right ventricle

  • ventricular zone

  • monocyte

  • bone marrow

  • bone marrow cells

  • skin of thigh

  • granulocyte

  • oocyte
Top expressed in
  • primitive streak

  • abdominal wall

  • medial ganglionic eminence

  • hair follicle

  • vas deferens

  • embryo

  • migratory enteric neural crest cell

  • mandibular prominence

  • Gonadal ridge

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • U6 snRNA binding
  • RNA binding
Cellular component
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • U4/U6 x U5 tri-snRNP complex
  • U6 snRNP
  • precatalytic spliceosome
  • U2-type precatalytic spliceosome
  • Lsm2-8 complex
Biological process
  • mRNA processing
  • RNA splicing
  • mRNA splicing, via spliceosome
  • RNA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51691

76522

Ensembl

ENSG00000128534

ENSMUSG00000044155

UniProt

O95777

Q6ZWM4

RefSeq (mRNA)

NM_016200

NM_133939

RefSeq (protein)

NP_057284

NP_598700

Location (UCSC)Chr 7: 118.18 – 118.2 MbChr 6: 18.85 – 18.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.[5][6]

This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.[6]

Interactions

LSM8 has been shown to interact with LSM2.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128534 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044155 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  6. ^ a b "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
  7. ^ Lehner, Ben; Sanderson Christopher M (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. ISSN 1088-9051. PMC 442147. PMID 15231747.
  8. ^ Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN 0888-7543. PMID 14667819.

Further reading

  • Khusial P, Plaag R, Zieve GW (2005). "LSm proteins form heptameric rings that bind to RNA via repeating motifs". Trends Biochem. Sci. 30 (9): 522–8. doi:10.1016/j.tibs.2005.07.006. PMID 16051491.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
  • Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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