LIME1

Protein-coding gene in the species Homo sapiens
LIME1
Identifiers
AliasesLIME1, LIME, LP8067, dJ583P15.4, Lck interacting transmembrane adaptor 1
External IDsOMIM: 609809; MGI: 1919949; HomoloGene: 56785; GeneCards: LIME1; OMA:LIME1 - orthologs
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[1]
Chromosome 2 (mouse)
Genomic location for LIME1
Genomic location for LIME1
Band2|2 H4Start181,021,871 bp[1]
End181,025,421 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right lobe of liver

  • blood

  • spleen

  • putamen

  • bone marrow cells

  • kidney

  • caudate nucleus

  • nucleus accumbens

  • pituitary gland

  • hippocampus proper
Top expressed in
  • granulocyte

  • islet of Langerhans

  • spleen

  • bone marrow

  • cerebellar cortex

  • thymus

  • hypothalamus

  • striatum of neuraxis

  • olfactory bulb

  • superior frontal gyrus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein kinase binding
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • extracellular space
  • U2-type post-mRNA release spliceosomal complex
  • B cell receptor complex
Biological process
  • B cell receptor signaling pathway
  • T cell receptor signaling pathway
  • adaptive immune response
  • immune system process
  • spliceosomal complex disassembly
  • regulation of transcription by RNA polymerase II
  • regulation of phosphatidylinositol 3-kinase signaling
  • regulation of I-kappaB kinase/NF-kappaB signaling
  • regulation of MAP kinase activity
  • regulation of release of sequestered calcium ion into cytosol
  • regulation of NIK/NF-kappaB signaling
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54923

72699

Ensembl

n/a

ENSMUSG00000090077

UniProt

Q9H400

Q9EQR5

RefSeq (mRNA)

NM_017806
NM_001305654
NM_001305655

NM_023684

RefSeq (protein)

NP_001292583
NP_001292584
NP_060276

NP_076173

Location (UCSC)n/aChr 2: 181.02 – 181.03 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Lck-interacting transmembrane adapter 1 is a protein that in humans is encoded by the LIME1 gene.[4][5]

LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells.[6][5]

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090077 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  5. ^ a b "Entrez Gene: LIME1 Lck interacting transmembrane adaptor 1".
  6. ^ Brdicková N, Brdicka T, Angelisová P, Horváth O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsí V (November 2003). "LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling". J Exp Med. 198 (10): 1453–62. doi:10.1084/jem.20031484. PMC 2194115. PMID 14610046.

Further reading

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Hur EM, Son M, Lee OH, et al. (2004). "LIME, a Novel Transmembrane Adaptor Protein, Associates with p56lck and Mediates T Cell Activation". J. Exp. Med. 198 (10): 1463–73. doi:10.1084/jem.20030232. PMC 2194117. PMID 14610044.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011. S2CID 340034.
  • Ahn E, Lee H, Yun Y (2006). "LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation". Blood. 107 (4): 1521–7. doi:10.1182/blood-2005-05-1859. PMID 16249387. S2CID 1139121.


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