LETMD1

Protein-coding gene in the species Homo sapiens
LETMD1
Identifiers
AliasesLETMD1, 1110019O13Rik, HCCR-1, HCCR-2, HCCR1, HCRR-2, LETM1 domain containing 1
External IDsMGI: 1915864; HomoloGene: 9128; GeneCards: LETMD1; OMA:LETMD1 - orthologs
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[1]
Chromosome 15 (mouse)
Genomic location for LETMD1
Genomic location for LETMD1
Band15|15 F1Start100,366,904 bp[1]
End100,377,045 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
    n/a
Top expressed in
  • brown adipose tissue

  • ascending aorta

  • dentate gyrus of hippocampal formation granule cell

  • cumulus cell

  • lumbar spinal ganglion

  • adrenal gland

  • Rostral migratory stream

  • superior frontal gyrus

  • aortic valve

  • primary visual cortex
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • ribosome binding
Cellular component
  • mitochondrial outer membrane
  • membrane
  • integral component of membrane
  • nucleoplasm
  • mitochondrion
  • mitochondrial inner membrane
Biological process
  • cellular metal ion homeostasis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25875

68614

Ensembl

ENSG00000050426

ENSMUSG00000037353

UniProt

Q6P1Q0

Q924L1

RefSeq (mRNA)
NM_001024668
NM_001024669
NM_001024670
NM_001024671
NM_001243689

NM_001300765
NM_015416

NM_134093
NM_001357982
NM_001357983
NM_001357984

RefSeq (protein)
NP_001230618
NP_001287694
NP_056231
NP_001338242
NP_001338245

NP_001338246
NP_001338248
NP_001338249
NP_001338250
NP_001338251
NP_001338252
NP_001338253
NP_001338254
NP_001338255
NP_001338256
NP_001338257
NP_001338259
NP_001338261
NP_001338262
NP_001338263
NP_001338264
NP_001338265
NP_001338266
NP_001338241
NP_001338244

NP_598854
NP_001344911
NP_001344912
NP_001344913

Location (UCSC)n/aChr 15: 100.37 – 100.38 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

LETM1 domain-containing protein 1 is a protein that in humans is encoded by the LETMD1 gene.[4][5][6]


References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037353 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Ko J, Lee YH, Hwang SY, Lee YS, Shin SM, Hwang JH, Kim J, Kim YW, Jang SW, Ryoo ZY, Kim IK, Namkoong SE, Kim JW (Jul 2003). "Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization". Oncogene. 22 (30): 4679–4689. doi:10.1038/sj.onc.1206624. PMID 12879013.
  5. ^ Qi ZY, Li Y, Ying K, Wu CQ, Tang R, Zhou ZX, Chen ZP, Hui GZ, Xie Y (Jun 2002). "Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes". J Neurooncol. 56 (3): 197–208. doi:10.1023/A:1015079705841. PMID 12061725. S2CID 23878825.
  6. ^ "Entrez Gene: LETMD1 LETM1 domain containing 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ko J, Shin SM, Oh YM, et al. (2004). "Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice". Oncogene. 23 (10): 1950–1953. doi:10.1038/sj.onc.1207356. PMID 14691448.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
  • Jung SS, Park HS, Lee IJ, et al. (2006). "The HCCR oncoprotein as a biomarker for human breast cancer". Clin. Cancer Res. 11 (21): 7700–7708. doi:10.1158/1078-0432.CCR-04-2609. PMID 16278390.
  • Cho GW, Shin SM, Namkoong H, et al. (2007). "The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression". Gene. 384: 18–26. doi:10.1016/j.gene.2006.07.006. PMID 16949218.


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