JNJ-10397049
Chemical compound
- none
- 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)urea
- 708275-58-5 Y
- 9869934
- 1701
- 8045625 N
- 1B419P24AV
- ChEMBL359632
- DTXSID501336831
- Interactive image
- BrC1=CC=C(NC(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)=O)C(Br)=C1
InChI
- InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1 N
- Key:RBKIJGLHFFQHBE-IRXDYDNUSA-N N
JNJ-10397049 is a potent and highly selective OX2 receptor antagonist. In animals, JNJ-10397049 was found to have sleep-promoting effects and to attenuate the reinforcing effects of ethanol.[1][2]
References
- ^ Dugovic C, Shelton JE, Aluisio LE, Fraser IC, Jiang X, Sutton SW, et al. (July 2009). "Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat". The Journal of Pharmacology and Experimental Therapeutics. 330 (1): 142–51. doi:10.1124/jpet.109.152009. PMID 19363060. S2CID 5676758.
- ^ Shoblock JR, Welty N, Aluisio L, Fraser I, Motley ST, Morton K, et al. (May 2011). "Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement". Psychopharmacology. 215 (1): 191–203. doi:10.1007/s00213-010-2127-x. PMID 21181123. S2CID 28874886.
- v
- t
- e
Orexin receptor modulators
- Antagonists: ACT-335827
- ACT-462206
- ACT-539313
- Almorexant
- AZD-4041
- C4X-3256 (INDV-2000)
- CR-5542
- Daridorexant
- Filorexant
- GSK-649868 (SB-649868)
- JNJ-61393215
- Lemborexant
- RTIOX-276
- SB-334867
- SB-408124
- Suvorexant
- TCS-1102
- Vornorexant (ORN-0829, TS-142)
- YZJ-1139
- Agonists: Danavorexton (TAK-925)
- Firazorexton
- Orexin (A, B)
- SB-668875
- Suntinorexton
- TAK-861
- TAK-994
- Antagonists: ACT-335827
- ACT-462206
- Almorexant
- Daridorexant
- EMPA
- Filorexant
- GSK-649868 (SB-649868)
- JNJ-10397049
- Lemborexant
- MK-1064
- MK-3697
- MK-8133
- Seltorexant
- Suvorexant
- TCS-1102
- TCS-OX2-29
- Vornorexant (ORN-0829, TS-142)
- YZJ-1139
This sedative-related article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e