InaD-like protein

Protein-coding gene in the species Homo sapiens
PATJ
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1VF6, 2D92, 2DAZ, 2DB5, 2DLU, 2DM8, 2DMZ, 2EHR, 4Q2N

Identifiers
AliasesPATJ, Cipp, InaD-like, hINADL, INADL, crumbs cell polarity complex component, PATJ crumbs cell polarity complex component
External IDsOMIM: 603199; MGI: 1277960; HomoloGene: 72199; GeneCards: PATJ; OMA:PATJ - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PATJ
Genomic location for PATJ
Band1p31.3Start61,742,477 bp[1]
End62,178,675 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for PATJ
Genomic location for PATJ
Band4|4 C6Start98,284,022 bp[2]
End98,607,840 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right ventricle

  • renal medulla

  • pons

  • cerebellar cortex

  • cerebellar hemisphere

  • Achilles tendon

  • right hemisphere of cerebellum

  • Skeletal muscle tissue of rectus abdominis

  • gingival epithelium

  • cerebellar vermis
Top expressed in
  • cerebellar vermis

  • lateral geniculate nucleus

  • lobe of cerebellum

  • medial dorsal nucleus

  • medial geniculate nucleus

  • motor neuron

  • facial motor nucleus

  • anterior horn of spinal cord

  • inferior colliculus

  • deep cerebellar nuclei
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • plasma membrane
  • apical part of cell
  • extracellular exosome
  • apical plasma membrane
  • membrane
  • bicellular tight junction
  • centrosome
  • microtubule organizing center
  • cytosol
  • cell junction
  • protein-containing complex
Biological process
  • intracellular signal transduction
  • bicellular tight junction assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10207

12695

Ensembl

ENSG00000132849

ENSMUSG00000061859

UniProt

Q8NI35

Q63ZW7

RefSeq (mRNA)

NM_005799
NM_176877
NM_176878
NM_001350145

NM_001005784
NM_001005787
NM_007704
NM_172696
NM_001355177

RefSeq (protein)

NP_795352
NP_001337074

NP_001005784
NP_001005787
NP_031730
NP_766284
NP_001342106

Location (UCSC)Chr 1: 61.74 – 62.18 MbChr 4: 98.28 – 98.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

InaD-like protein is a protein that in humans is encoded by the PATJ gene.[5][6][7]

Function

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.[7]

Interactions

INADL has been shown to interact with MPP5.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132849 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061859 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Philipp S, Flockerzi V (Sep 1997). "Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster". FEBS Lett. 413 (2): 243–8. doi:10.1016/S0014-5793(97)00877-6. PMID 9280290.
  6. ^ Soejima H, Kawamoto S, Akai J, Miyoshi O, Arai Y, Morohka T, Matsuo S, Niikawa N, Kimura A, Okubo K, Mukai T (May 2001). "Isolation of novel heart-specific genes using the BodyMap database". Genomics. 74 (1): 115–20. doi:10.1006/geno.2001.6527. PMID 11374908.
  7. ^ a b "Entrez Gene: INADL InaD-like (Drosophila)".
  8. ^ Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (Apr 2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.

Further reading

  • Fanning AS, Anderson JM (1999). "PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane". J. Clin. Invest. 103 (6): 767–72. doi:10.1172/JCI6509. PMC 408156. PMID 10079096.
  • Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–2. doi:10.1006/geno.1996.0177. PMID 8617505.
  • Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694. S2CID 36534759.
  • Vaccaro P, Brannetti B, Montecchi-Palazzi L, Philipp S, Helmer Citterich M, Cesareni G, Dente L (2001). "Distinct binding specificity of the multiple PDZ domains of INADL, a human protein with homology to INAD from Drosophila melanogaster". J. Biol. Chem. 276 (45): 42122–30. doi:10.1074/jbc.M104208200. PMID 11509564.
  • Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E (2002). "The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons". J. Biol. Chem. 277 (19): 16655–61. doi:10.1074/jbc.M201087200. PMID 11872753.
  • Roh MH, Makarova O, Liu CJ, Shin K, Lee S, Laurinec S, Goyal M, Wiggins R, Margolis B (2002). "The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost". J. Cell Biol. 157 (1): 161–72. doi:10.1083/jcb.200109010. PMC 2173254. PMID 11927608.
  • Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells". J. Biol. Chem. 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
  • Roh MH, Liu CJ, Laurinec S, Margolis B (2002). "The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions". J. Biol. Chem. 277 (30): 27501–9. doi:10.1074/jbc.M201177200. PMID 12021270.
  • Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
  • Roh MH, Fan S, Liu CJ, Margolis B (2004). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". J. Cell Sci. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187. S2CID 4482921.
  • Li Y, Karnak D, Demeler B, Margolis B, Lavie A (2005). "Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes". EMBO J. 23 (14): 2723–33. doi:10.1038/sj.emboj.7600294. PMC 514954. PMID 15241471.
  • Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A (2005). "PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells". J. Cell Sci. 118 (Pt 17): 4049–57. doi:10.1242/jcs.02528. PMID 16129888. S2CID 19826254.
  • Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G (2007). "Uncovering Quantitative Protein Interaction Networks for Mouse PDZ Domains using Protein Microarrays". J. Am. Chem. Soc. 128 (17): 5913–22. doi:10.1021/ja060943h. PMC 2533859. PMID 16637659.
  • Wells CD, Fawcett JP, Traweger A, Yamanaka Y, Goudreault M, Elder K, Kulkarni S, Gish G, Virag C, Lim C, Colwill K, Starostine A, Metalnikov P, Pawson T (2006). "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells". Cell. 125 (3): 535–48. doi:10.1016/j.cell.2006.02.045. PMID 16678097. S2CID 18651810.
  • v
  • t
  • e
  • 2d92: Solution structure of the fifth PDZ domain of InaD-like protein
    2d92: Solution structure of the fifth PDZ domain of InaD-like protein
  • 2daz: Solution structure of the 7th PDZ domain of InaD-like protein
    2daz: Solution structure of the 7th PDZ domain of InaD-like protein
  • 2db5: Solution structure of the first PDZ domain of InaD-like protein
    2db5: Solution structure of the first PDZ domain of InaD-like protein
  • 2dlu: Solution structure of the second PDZ domain of human InaD-like protein
    2dlu: Solution structure of the second PDZ domain of human InaD-like protein
  • 2dm8: Solution structure of the eighth PDZ domain of human InaD-like protein
    2dm8: Solution structure of the eighth PDZ domain of human InaD-like protein
  • 2dmz: Solution structure of the third PDZ domain of human InaD-like protein
    2dmz: Solution structure of the third PDZ domain of human InaD-like protein


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