IVNS1ABP

Protein-coding gene in the species Homo sapiens
IVNS1ABP
Identifiers
AliasesIVNS1ABP, FLARA3, HSPC068, KLHL39, ND1, NS-1, NS1-BP, NS1BP, influenza virus NS1A binding protein, ARA3, IMD70
External IDsOMIM: 609209; MGI: 2152389; HomoloGene: 31384; GeneCards: IVNS1ABP; OMA:IVNS1ABP - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for IVNS1ABP
Genomic location for IVNS1ABP
Band1q25.3Start185,296,388 bp[1]
End185,317,273 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for IVNS1ABP
Genomic location for IVNS1ABP
Band1|1 G1Start151,220,228 bp[2]
End151,240,173 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • tibia

  • minor salivary glands

  • ventricular zone

  • Achilles tendon

  • skin of abdomen

  • bone marrow

  • rectum

  • skin of leg

  • bone marrow cells
Top expressed in
  • epithelium of lens

  • Paneth cell

  • myocardium of ventricle

  • medullary collecting duct

  • efferent ductule

  • olfactory epithelium

  • cardiac muscle tissue of left ventricle

  • primitive streak

  • cumulus cell

  • aortic valve
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • actin cytoskeleton
  • spliceosomal complex
  • cytoskeleton
  • nucleus
  • transcription regulator complex
  • nucleoplasm
  • cytoplasm
  • cytosol
Biological process
  • negative regulation of intrinsic apoptotic signaling pathway
  • viral process
  • transcription by RNA polymerase III
  • RNA splicing
  • response to virus
  • negative regulation of protein ubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10625

117198

Ensembl

ENSG00000116679

ENSMUSG00000023150

UniProt

Q9Y6Y0

Q920Q8

RefSeq (mRNA)

NM_006469
NM_016389

NM_001039511
NM_001039512
NM_028582
NM_054102
NM_001359262

NM_001359263

RefSeq (protein)

NP_006460

NP_001034600
NP_001034601
NP_473443
NP_001346191
NP_001346192

Location (UCSC)Chr 1: 185.3 – 185.32 MbChr 1: 151.22 – 151.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Influenza virus NS1A-binding protein is a protein that in humans is encoded by the IVNS1ABP gene.[5][6][7]

In melanocytic cells IVNS1ABP gene expression may be regulated by MITF.[8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116679 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023150 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wolff T, O'Neill RE, Palese P (Sep 1998). "NS1-Binding protein (NS1-BP): a novel human protein that interacts with the influenza A virus nonstructural NS1 protein is relocalized in the nuclei of infected cells". J Virol. 72 (9): 7170–80. doi:10.1128/JVI.72.9.7170-7180.1998. PMC 109939. PMID 9696811.
  6. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  7. ^ "Entrez Gene: IVNS1ABP influenza virus NS1A binding protein".
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

  • Perconti G, Ferro A, Amato F, et al. (2008). "The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control". Biochim. Biophys. Acta. 1773 (12): 1774–85. doi:10.1016/j.bbamcr.2007.09.002. PMID 17996313.
  • Dunham EE, Stevens EA, Glover E, Bradfield CA (2006). "The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein". Mol. Pharmacol. 70 (1): 8–15. doi:10.1124/mol.106.024380. PMID 16582008. S2CID 8164208.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Harris CE, Boden RA, Astell CR (1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". J. Virol. 73 (1): 72–80. doi:10.1128/JVI.73.1.72-80.1999. PMC 103810. PMID 9847309.


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