INTS6

Protein-coding gene in the species Homo sapiens
INTS6
Identifiers
AliasesINTS6, DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, Notchl2, integrator complex subunit 6
External IDsOMIM: 604331; MGI: 1202397; HomoloGene: 8121; GeneCards: INTS6; OMA:INTS6 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for INTS6
Genomic location for INTS6
Band13q14.3Start51,354,077 bp[1]
End51,454,264 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for INTS6
Genomic location for INTS6
Band14|14 D1Start62,913,779 bp[2]
End62,998,618 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • Achilles tendon

  • optic nerve

  • right testis

  • left testis

  • epithelium of colon

  • tonsil

  • body of pancreas

  • ventricular zone

  • gingival epithelium
Top expressed in
  • spermatocyte

  • spermatid

  • tail of embryo

  • seminiferous tubule

  • Gonadal ridge

  • lacrimal gland

  • genital tubercle

  • human fetus

  • gastrula

  • cumulus cell
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • transmembrane signaling receptor activity
Cellular component
  • integrator complex
  • actin cytoskeleton
  • nucleoplasm
  • nucleus
Biological process
  • snRNA processing
  • snRNA transcription by RNA polymerase II
  • signal transduction
  • snRNA 3'-end processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26512

18130

Ensembl

ENSG00000102786

ENSMUSG00000035161

UniProt

Q9UL03

Q6PCM2

RefSeq (mRNA)

NM_001039937
NM_001039938
NM_001306091
NM_012141

NM_008715

RefSeq (protein)

NP_001035026
NP_001035027
NP_001293020
NP_036273

NP_032741

Location (UCSC)Chr 13: 51.35 – 51.45 MbChr 14: 62.91 – 63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene.[5][6][7]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The protein encoded by this gene is a DEAD box protein that is part of a complex that interacts with the C-terminus of RNA polymerase II and is involved in 3' end processing of snRNAs. In addition, this gene is a candidate tumor suppressor and located in the critical region of loss of heterozygosity (LOH). Three transcript variants encoding two different isoforms have been found for this gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102786 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035161 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.
  6. ^ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
  7. ^ a b "Entrez Gene: INTS6 integrator complex subunit 6".

Further reading

  • Buchsbaum S, Morris C, Bochard V, Jalinot P (2007). "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle". Oncogene. 26 (35): 5132–44. doi:10.1038/sj.onc.1210314. PMID 17310990. S2CID 2886919.
  • Hernández M, Papadopoulos N, Almeida TA (2006). "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions". Cancer Genet. Cytogenet. 163 (1): 91–2. doi:10.1016/j.cancergencyto.2005.04.014. PMID 16271964.
  • Röpke A, Buhtz P, Böhm M, et al. (2005). "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer". Oncogene. 24 (44): 6667–75. doi:10.1038/sj.onc.1208824. PMID 16007164. S2CID 12129480.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wieland I, Sell C, Weidle UH, Wieacker P (2005). "Ectopic expression of DICE1 suppresses tumor cell growth". Oncol. Rep. 12 (2): 207–11. doi:10.3892/or.12.2.207. PMID 15254679.
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Li WJ, Hu N, Su H, et al. (2003). "Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma". Oncogene. 22 (2): 314–8. doi:10.1038/sj.onc.1206098. PMID 12527901. S2CID 10839440.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Wieland I, Röpke A, Stumm M, et al. (2002). "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells". Oncol. Res. 12 (11–12): 491–500. doi:10.3727/096504001108747503. PMID 11939413.
  • Camargo AA, Nunes DN, Samaia HB, et al. (2002). "Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12". Braz. J. Med. Biol. Res. 34 (10): 1237–45. doi:10.1590/s0100-879x2001001000002. PMID 11593297.


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