IFIT3

Protein-coding gene in the species Homo sapiens
IFIT3
Identifiers
AliasesIFIT3, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G, cig41, interferon induced protein with tetratricopeptide repeats 3
External IDsOMIM: 604650; MGI: 1101055; HomoloGene: 1189; GeneCards: IFIT3; OMA:IFIT3 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for IFIT3
Genomic location for IFIT3
Band10q23.31Start89,327,307 bp[1]
End89,377,473 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for IFIT3
Genomic location for IFIT3
Band19|19 C1Start34,560,931 bp[2]
End34,566,131 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trigeminal ganglion

  • jejunal mucosa

  • pericardium

  • lower lobe of lung

  • spinal ganglia

  • human penis

  • palpebral conjunctiva

  • monocyte

  • endothelial cell

  • synovial joint
Top expressed in
  • right kidney

  • granulocyte

  • human kidney

  • thymus

  • jejunum

  • lung

  • colon

  • adrenal gland

  • spleen

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • identical protein binding
  • protein binding
  • molecular function
  • RNA binding
Cellular component
  • cytoplasm
  • mitochondrion
  • cytosol
Biological process
  • immune system process
  • response to virus
  • innate immune response
  • negative regulation of apoptotic process
  • defense response to virus
  • type I interferon signaling pathway
  • negative regulation of cell population proliferation
  • cellular response to interferon-alpha
  • response to bacterium
  • cellular response to interferon-beta
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3437

15959

Ensembl

ENSG00000119917

ENSMUSG00000074896

UniProt

O14879

Q64345

RefSeq (mRNA)

NM_001549
NM_001031683
NM_001289758
NM_001289759

NM_010501

RefSeq (protein)

NP_001026853
NP_001276687
NP_001276688
NP_001540

NP_034631

Location (UCSC)Chr 10: 89.33 – 89.38 MbChr 19: 34.56 – 34.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 (ISG49),[5] is a protein that in humans is encoded by the IFIT3 gene.[5][6][7][8] It plays a part in the innate immune response to viruses in response to type I interferon signaling.[5]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119917 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074896 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, et al. (2012). "Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis". PLOS Pathogens. 8 (5): e1002712. doi:10.1371/journal.ppat.1002712. PMC 3355090. PMID 22615570.
  6. ^ de Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ (December 1998). "IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes". Genomics. 54 (2): 267–277. doi:10.1006/geno.1998.5555. PMID 9828129.
  7. ^ Zhu H, Cong JP, Shenk T (December 1997). "Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs". Proceedings of the National Academy of Sciences of the United States of America. 94 (25): 13985–13990. Bibcode:1997PNAS...9413985Z. doi:10.1073/pnas.94.25.13985. PMC 28419. PMID 9391139.
  8. ^ "Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3".

Further reading

  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, et al. (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–221. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
  • Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–197. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
  • Yu M, Tong JH, Mao M, Kan LX, Liu MM, Sun YW, et al. (July 1997). "Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7406–7411. Bibcode:1997PNAS...94.7406Y. doi:10.1073/pnas.94.14.7406. PMC 23834. PMID 9207104.


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