Hygromycin-B kinase
hygromycin B kinase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 2.7.1.119 | ||||||||
CAS no. | 88361-67-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, a hygromycin-B kinase (EC 2.7.1.119) is an enzyme that catalyzes the chemical reaction
- ATP + hygromycin B ADP + 7"-O-phosphohygromycin
Thus, the two substrates of this enzyme are ATP and hygromycin B, whereas its two products are ADP and 7''-O-phosphohygromycin.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:hygromycin-B 7"-O-phosphotransferase. This enzyme is also called hygromycin B phosphotransferase.
References
- Zalacain M, Pardo JM, Jimenez A (1987). "Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus". Eur. J. Biochem. 162 (2): 419–22. doi:10.1111/j.1432-1033.1987.tb10618.x. hdl:10261/57133. PMID 3026811.
- Pardo JM, Malpartida F, Rico M, Jimenez A (1985). "Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism". J. Gen. Microbiol. 131 (6): 1289–1298. doi:10.1099/00221287-131-6-1289. hdl:10261/57242. PMID 2995542.
- v
- t
- e
phosphotransferase/kinase
(PO4)
2.7.1: OH acceptor | |
---|---|
2.7.2: COOH acceptor | |
2.7.3: N acceptor | |
2.7.4: PO4 acceptor |
(P2O7)
(PO4-nucleoside)
Polymerase |
| ||||
---|---|---|---|---|---|
Phosphorolytic 3' to 5' exoribonuclease | |||||
Nucleotidyltransferase | |||||
Guanylyltransferase | |||||
Other |
Phosphatidyltransferases | |
---|---|
Glycosyl-1-phosphotransferase |
(PO4; protein acceptor)
2.7.10: protein-tyrosine |
|
---|---|
2.7.11: protein-serine/threonine |
|
2.7.12: protein-dual-specificity |
|
2.7.13: protein-histidine |