HLA-Cw4 |
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(MHC Class I, C cell surface antigen) |
HLA-Cw4 |
About |
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Protein | transmembrane receptor/ligand |
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Structure | αβ heterodimer |
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Subunits | HLA-Cw*04--, β2-microglobulin |
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Older names | - |
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Subtypes |
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Subtype | allele | Available structures |
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Cw4 | *0401 | |
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{{{cNick2}}} | *04{{{cAllele2}}} | |
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{{{cNick3}}} | *04{{{cAllele3}}} | |
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{{{cNick4}}} | *04{{{cAllele4}}} | |
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Rare alleles |
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Subtype | allele | Available structures |
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Cw403 | *0403 | |
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{{{rnick2}}} | *04{{{rallele2}}} | |
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{{{rnick3}}} | *04{{{rallele3}}} | |
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Alleles link-out to IMGT/HLA database at EBI |
HLA-Cw4 (Cw4) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw4 is determined by the antibody recognition of α4 subset of HLA-Cw α-chains. For the serotype Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus.[1] Cw4 and Cw*04 are almost synonymous in meaning. Cw4 is more common in Southeast Europe, where it is part of the Cw4-B35 haplotype.
Serotype
Cw4 recognition of some HLA Cw*04 gene products[2] Cw*04 | Cw4 | Cw403 | Cw6 | Sample |
allele | % | % | % | size (N) |
*0401 | 98 | 0 | 0 | 736 |
*0403 | 37 | 5 | 17 | 25 |
Alleles
HLA Cw*0401 frequenciesStudy population | Freq. (in %)[3] |
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Mexico Mixe Oaxaca | 37.8 |
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Mexico Mixtec Oaxaca | 37.3 |
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USA N. Mexico Canoncito N… | 31.7 |
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Mexico Zaptotec Oaxaca | 30.6 |
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Iran Baloch | 28.6 |
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Australia Indig. Cape Yor… | 27.5 |
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Australia Indig.Yuendumu | 26.8 |
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Australia Indig. Groote E… | 25.3 |
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Lebanon | 24.3 |
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Israel Arab Druse | 22.5 |
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Georgia Tbilisi Kurds | 22.4 |
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Brazil Terena | 22.3 |
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Georgia Tbilisi Georgian… | 22.0 |
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India Tamil Nadu Nadar | 21.3 |
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Mali Bandiagara | 21.3 |
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Taiwan Ami | 20.9 |
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Papua New Guinea Wanigela | 20.8 |
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USA African Americans pop… | 19.6 |
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Senegal Niokholo Mandenka | 19.5 |
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Cameroon Beti | 18.7 |
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Indig. Australian Kimberl… | 17.9 |
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Papua New Guinea Wosera | 17.0 |
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Italy North pop 1 | 16.7 |
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New Caledonia | 16.7 |
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Morocco Nador Metalsa (be… | 15.9 |
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Portugal Centre pop 2 | 15.8 |
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Cameroon Sawa | 15.4 |
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India Mumbai Marathas | 15.4 |
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Iran Tehran | 15.4 |
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USA Hispanic | 15.0 |
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PNG West Schrader Ranges | 14.8 |
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Zimbabwe Harare Shona | 14.8 |
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Swiss Geneva | 14.5 |
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Zambia Lusaka | 14.4 |
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Uganda Kampala | 14.1 |
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Brazil | 13.7 |
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Sudanese | 13.5 |
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France West | 13.4 |
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Tibetan | 13.3 |
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Finland | 13.3 |
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Kenya Luo | 13.2 |
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Cameroon Bamileke | 13.0 |
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Philippines Ivatan | 13.0 |
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Kenya | 12.9 |
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Singapore Riau Malay | 12.2 |
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India North Delhi | 11.7 |
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Tunisia | 11.6 |
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Kenya Nandi | 11.5 |
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Russia Tuva pop 2 | 11.5 |
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Taiwan Bunun | 11.4 |
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USA Caucasian pop2 | 11.1 |
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India West Coast Parsis | 11.0 |
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China Qinghai Hui | 10.9 |
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Czech Republic | 10.8 |
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India New Delhi | 10.7 |
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Spain Eastern Andalusia | 10.4 |
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UK Caucasians | 10.1 |
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Cameroon Pygmy Baka | 10.0 |
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China Beijing | 10.0 |
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Jordan Amman | 10.0 |
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Singapore Javanese | 10.0 |
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Papua New Guinea Madang | 9.5 |
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Saudi Arabia Guraiat and … | 9.5 |
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Australia New South Wales | 9.4 |
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USA Alaska Yupik Natives | 9.3 |
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Bulgaria Gipsy | 9.1 |
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Mex. Chihuahua Tarahumara | 9.1 |
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German Essen | 9.0 |
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France South East | 8.9 |
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Taiwan Paiwan | 8.8 |
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China Inner Mongolia | 8.3 |
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Ireland Northern | 8.3 |
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Venezuela Perija Yucpa | 8.3 |
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South Korea (1) | 8.2 |
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China North Han | 7.6 |
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USA South Dakota Lakota S… | 7.4 |
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Taiwan Atayal | 7.1 |
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India West Bhils | 7.0 |
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PNG Karimui Plateau | 6.9 |
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Taiwan Siraya | 6.9 |
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Taiwan Thao | 6.7 |
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Japan (5) | 6.5 |
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Thailand | 6.0 |
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China Guangzhou | 5.6 |
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USA Asian | 5.6 |
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Ireland South | 5.4 |
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PNG Eastern Highlands Gor… | 4.7 |
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Japan Central | 4.6 |
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Spain Eastern Andalusia G… | 4.5 |
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China South Han | 4.4 |
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South Africa Natal Tamil | 4.2 |
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American Samoa | 4.0 |
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Taiwan Saisiat | 3.9 |
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Papua New Guinea New Brit… | 3.6 |
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Taiwan Minnan pop 1 | 3.4 |
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USA Hawaii Okinawa | 3.3 |
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China Guangdong Meizhou H… | 3.0 |
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India Khandesh Pawra | 3.0 |
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Taiwan Puyuma | 3.0 |
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Allele frequencies presented, only |
HLA Cw*0403 frequenciesStudy population | Freq. (in %)[3] |
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PNG West Schrader Ranges | 45.9 |
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Taiwan Tao | 40.0 |
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PMG Eastern Highlands Gor… | 34.9 |
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PNG Madang | 25.0 |
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PNG Wanigela | 16.0 |
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Australia Indig. Cape Yor… | 15.7 |
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Australia Indig. Yuendumu | 15.1 |
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Australia Indig. Groote E… | 12.3 |
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Taiwan Puyuma | 12.0 |
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PNG Karimui Plateau | 11.9 |
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Taiwan Pazeh | 11.8 |
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Taiwan Thao | 11.7 |
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New Caledonia | 11.1 |
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Singapore Riau Malay | 9.8 |
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PNG New Britain Rabaul | 8.9 |
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PNG Wosera | 8.0 |
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Singapore Javanese | 7.0 |
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Taiwan Rukai | 7.0 |
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Taiwan Bunun | 6.4 |
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American Samoa | 6.0 |
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Thailand | 5.3 |
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Philippines Ivatan | 5.0 |
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Taiwan Siraya | 4.9 |
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Taiwan Tsou | 4.9 |
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Australia Indig. Kimberly | 3.6 |
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Taiwan Atayal | 3.3 |
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South Africa Natal Tamil | 3.1 |
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Taiwan Ami | 2.6 |
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China South Han | 2.1 |
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USA Asian | 2.0 |
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Taiwan Hakka | 1.8 |
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China Qinghai Hui | 1.4 |
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Iran Tehran | 1.3 |
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China Guangdong Meizhou H… | 1.0 |
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China Inner Mongolia | 1.0 |
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India West Coast Parsis | 1.0 |
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Taiwan Minnan pop 1 | 1.0 |
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Taiwan Paiwan | 1.0 |
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India New Delhi | 0.9 |
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Russia Tuva | 0.9 |
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China Tibetan | 0.6 |
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Allele frequencies presented, only |
References
- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ^ a b Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
- HLA-C
- Cw1
- Cw2
- Cw3
- Cw4
- Cw5
- Cw6
- Cw7
- Cw8
- Cw*12
- Cw*13
- Cw*14
- Cw*15
- Cw*16
- Cw*17
- Cw*18
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