HEBP1

HEBP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2GOV, 2HVA, 4A1M

Identifiers
AliasesHEBP1, HBP, HEBP, heme binding protein 1
External IDsOMIM: 605826; MGI: 1333880; HomoloGene: 8407; GeneCards: HEBP1; OMA:HEBP1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for HEBP1
Genomic location for HEBP1
Band12p13.1Start12,974,870 bp[1]
End13,000,265 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for HEBP1
Genomic location for HEBP1
Band6|6 G1Start135,114,520 bp[2]
End135,175,020 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • duodenum

  • mucosa of ileum

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • trabecular bone

  • parotid gland

  • left adrenal cortex

  • left lobe of thyroid gland
Top expressed in
  • fetal liver hematopoietic progenitor cell

  • left lobe of liver

  • yolk sac

  • tibiofemoral joint

  • spleen

  • white adipose tissue

  • subcutaneous adipose tissue

  • gastrula

  • migratory enteric neural crest cell

  • efferent ductule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • heme binding
Cellular component
  • cytoplasm
  • extracellular region
  • extracellular exosome
  • cytosol
Biological process
  • circadian rhythm
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

50865

15199

Ensembl

ENSG00000013583

ENSMUSG00000042770

UniProt

Q9NRV9

Q9R257

RefSeq (mRNA)

NM_015987

NM_013546

RefSeq (protein)

NP_057071

NP_038574

Location (UCSC)Chr 12: 12.97 – 13 MbChr 6: 135.11 – 135.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heme binding protein 1 is a protein that in humans is encoded by the HEBP1 gene.[5]

Function

The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000013583 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042770 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Heme binding protein 1".

Further reading

  • Jacob Blackmon B, Dailey TA, Lianchun X, Dailey HA (Nov 2002). "Characterization of a human and mouse tetrapyrrole-binding protein". Archives of Biochemistry and Biophysics. 407 (2): 196–201. doi:10.1016/s0003-9861(02)00471-x. PMID 12413491.
  • Gao JL, Guillabert A, Hu J, Le Y, Urizar E, Seligman E, Fang KJ, Yuan X, Imbault V, Communi D, Wang JM, Parmentier M, Murphy PM, Migeotte I (Feb 2007). "F2L, a peptide derived from heme-binding protein, chemoattracts mouse neutrophils by specifically activating Fpr2, the low-affinity N-formylpeptide receptor". Journal of Immunology. 178 (3): 1450–6. doi:10.4049/jimmunol.178.3.1450. PMID 17237393.
  • Micaelo NM, Macedo AL, Goodfellow BJ, Félix V (Nov 2010). "Tetrapyrrole binding affinity of the murine and human p22HBP heme-binding proteins". Journal of Molecular Graphics & Modelling. 29 (3): 396–405. doi:10.1016/j.jmgm.2010.07.008. PMID 20800521.
  • Migeotte I, Riboldi E, Franssen JD, Grégoire F, Loison C, Wittamer V, Detheux M, Robberecht P, Costagliola S, Vassart G, Sozzani S, Parmentier M, Communi D (Jan 2005). "Identification and characterization of an endogenous chemotactic ligand specific for FPRL2". The Journal of Experimental Medicine. 201 (1): 83–93. doi:10.1084/jem.20041277. PMC 2212760. PMID 15623572.
  • Devosse T, Dutoit R, Migeotte I, De Nadai P, Imbault V, Communi D, Salmon I, Parmentier M (Aug 2011). "Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3". Journal of Immunology. 187 (3): 1475–85. doi:10.4049/jimmunol.1003545. PMID 21709160.
  • Zylka MJ, Reppert SM (Dec 1999). "Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches". Brain Research. Molecular Brain Research. 74 (1–2): 175–81. doi:10.1016/s0169-328x(99)00277-6. PMID 10640688.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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